Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00088)
Xenobiotics Name
Dexamethasone
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5743"></iframe>
3D MOL 2D MOL
PubChem CID
5743
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Asparagine synthetase (ASNS) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2]
Cytochrome P450 2S1 (CYP2S1) DME Info Homo sapiens [3]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [4]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [5]
Amidophosphoribosyltransferase (GPAT) DME Info Homo sapiens [6]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [7], [8]
DME(s) Induced by This Xenobiotics
Acetyl-CoA synthetase (ACSS2) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-I alpha (ADH1A) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-I gamma (ADH1C) DME Info Homo sapiens [1]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [1]
Alkaline phosphatase (ALPL) DME Info Homo sapiens [9]
Copper amine oxidase (AOC3) DME Info Homo sapiens [1]
Aldehyde oxidase (AOX1) DME Info Homo sapiens [1]
Aquaporin adipose (AQP7) DME Info Homo sapiens [1], [10]
Carbonic anhydrase II (CA2) DME Info Homo sapiens [1]
Catalase (CAT) DME Info Homo sapiens [1]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [11]
Carboxylesterase 2 (CES2) DME Info Homo sapiens [11]
Microsomal cytochrome MCB5 (CYB5A) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [12], [13]
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [14]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [15], [16]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [17]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [18], [19]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [17]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [20]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [21]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [22], [19]
Dicarbonyl/L-xylulose reductase (DCXR) DME Info Homo sapiens [1]
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [1]
Fatty acid desaturase 1 (FADS1) DME Info Homo sapiens [1]
Glutamine synthetase (GLUL) DME Info Homo sapiens [1]
Glutathione reductase (GSR) DME Info Homo sapiens [23]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [24]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [25]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [26]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [27], [26]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [28]
Metallothionein-1A (MT1A) DME Info Homo sapiens [1]
Metallothionein-2A (MT2A) DME Info Homo sapiens [1]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [10]
Phosphorylethanolamine transferase (PCYT2) DME Info Homo sapiens [1]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [29]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [1]
Tryptophan oxygenase (TRPO) DME Info Homo sapiens [30]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [31]
References
1 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
2 Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact. 2009 May 15;179(2-3):288-96.
3 CYP2S1 is negatively regulated by corticosteroids in human cell lines. Toxicol Lett. 2012 Feb 25;209(1):30-4.
4 Effects of nitroglycerin and dexamethasone on nitric oxide and endothelin derived from alveolar macrophages in patients with mild and middle asthma. Hunan Yi Ke Da Xue Xue Bao. 2000 Aug 28;25(4):363-6.
5 Dexamethasone induces caveolin-1 in vascular endothelial cells: implications for attenuated responses to VEGF. Am J Physiol Cell Physiol. 2013 Apr 15;304(8):C790-800.
6 Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
7 15-Hydroxyprostaglandin dehydrogenase can be induced by dexamethasone and other glucocorticoids at the therapeutic level in A549 human lung adenocarcinoma cells. Arch Biochem Biophys. 2005 Mar 1;435(1):50-5.
8 Indomethacin-enhanced anticancer effect of arsenic trioxide in A549 cell line: involvement of apoptosis and phospho-ERK and p38 MAPK pathways. Biomed Res Int. 2013;2013:237543.
9 Parathyroid hormone 1-34 reduces dexamethasone-induced terminal differentiation in human articular chondrocytes. Toxicology. 2016 Aug 10;368-369:116-128.
10 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
11 Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats. Drug Metab Dispos. 2000 Feb;28(2):186-91.
12 The modulation of aromatase and estrogen receptor alpha in cultured human dermal papilla cells by dexamethasone: a novel mechanism for selective action of estrogen via estrogen receptor beta? J Invest Dermatol. 2006 Sep;126(9):2010-8.
13 Regulation of aromatase and 5alpha-reductase by 25-hydroxyvitamin D(3), 1alpha,25-dihydroxyvitamin D(3), dexamethasone and progesterone in prostate cancer cells. J Steroid Biochem Mol Biol. 2005 Feb;94(1-3):151-7.
14 Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme. Biochim Biophys Acta. 2008 Nov-Dec;1781(11-12):718-23.
15 Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: a 10-year follow-up. Xenobiotica. 2000 Jun;30(6):589-607.
16 Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter. Mol Pharmacol. 2008 Feb;73(2):451-60.
17 Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes. Drug Metab Dispos. 2005 Jul;33(7):1004-16.
18 Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Mol Pharmacol. 2005 Sep;68(3):747-57.
19 Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):86-96.
20 Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors. Toxicol In Vitro. 2013 Oct;27(7):2049-60.
21 Development of stably transfected human and rat hepatoma cell lines for the species-specific assessment of xenobiotic response enhancer module (XREM)-dependent induction of drug metabolism. Toxicology. 2010 Nov 9;277(1-3):11-9.
22 Molecular, cellular, and tissue impact of depleted uranium on xenobiotic-metabolizing enzymes. Arch Toxicol. 2014 Feb;88(2):227-39.
23 Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis. PLoS One. 2012;7(1):e30443.
24 Dexamethasone induces human glutathione S transferase alpha 1 (hGSTA1) expression through the activation of glucocorticoid receptor (hGR). Toxicology. 2017 Jun 15;385:59-66.
25 Reciprocal regulation of 11beta-hydroxysteroid dehydrogenase 1 and glucocorticoid receptor expression by dexamethasone inhibits human coronary artery smooth muscle cell proliferation in vitro. Mol Cell Biochem. 2011 Jan;346(1-2):69-79.
26 SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004;21(6):477-83.
27 Monoamine oxidase-A is a major target gene for glucocorticoids in human skeletal muscle cells. FASEB J. 2005 Aug;19(10):1359-61.
28 Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo. Mol Med. 2012 May 9;18:423-32.
29 Transcriptional regulation of human paraoxonase 1 by PXR and GR in human hepatoma cells. Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):348-54.
30 Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression. Toxicol Appl Pharmacol. 2014 Oct 1;280(1):138-48.
31 Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1. Mol Pharmacol. 2005 Mar;67(3):845-55.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.