Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00140)
Xenobiotics Name
Zoledronic acid
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
68740
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-I alpha (ADH1A) DME Info Homo sapiens [1]
Asparagine synthetase (ASNS) DME Info Homo sapiens [2]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [3]
Sodium/potassium-transporting ATPase gamma (FXYD2) DME Info Homo sapiens [2]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [4]
Cysteinyl-conjugate N-acetyltransferase (NAT8) DME Info Homo sapiens [2]
Phosphodiesterase 5A (PDE5A) DME Info Homo sapiens [5]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [2]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [6]
DME(s) Induced by This Xenobiotics
Acetyl-CoA synthetase (ACSS2) DME Info Homo sapiens [5]
Aminomuconic semialdehyde dehydrogenase (ALDH12) DME Info Homo sapiens [7]
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [5]
Alanyl aminopeptidase (ANPEP) DME Info Homo sapiens [5]
Bile acid-CoA thioesterase (BAAT) DME Info Homo sapiens [8]
Choline/ethanolaminephosphotransferase 1 (CEPT1) DME Info Homo sapiens [5]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [6]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [5]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [2]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [1]
Mevalonate pyrophosphate decarboxylase (MPD) DME Info Homo sapiens [9]
Steroid 5-alpha-reductase 2 (SRD5A2) DME Info Homo sapiens [5], [2]
References
1 Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy. Leukemia. 2010 Mar;24(3):552-62.
2 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
3 Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
4 The inhibition, reactivation and mechanism of VX-, sarin-, fluoro-VX and fluoro-sarin surrogates following their interaction with HuAChE and HuBuChE. Chem Biol Interact. 2018 Aug 1;291:220-227.
5 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
6 Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid. Cancer Chemother Pharmacol. 2008 Apr;61(5):791-802.
7 The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells. Cancer Res. 2004 Dec 1;64(23):8778-81.
8 Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
9 The novel antibacterial compound walrycin A induces human PXR transcriptional activity. Toxicol Sci. 2012 May;127(1):225-35.

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