Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00186)
Xenobiotics Name
Isotretinoin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
5282379
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acyl-CoA thioesterase 2 (ACOT2) DME Info Homo sapiens [1]
Acid phosphatase-like protein 1 (ACP6) DME Info Homo sapiens [1]
Aldo-keto reductase 1A1 (AKR1A1) DME Info Homo sapiens [1]
Cytidine aminohydrolase (CDA) DME Info Homo sapiens [1]
Microsomal cytochrome MCB5 (CYB5A) DME Info Homo sapiens [1]
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [2]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [2]
Lauric acid omega-hydroxylase (CYP4A11) DME Info Homo sapiens [2]
Cytochrome P450 4F2 (CYP4F2) DME Info Homo sapiens [1]
Leukotriene B4 omega-hydroxylase (CYP4F3) DME Info Homo sapiens [1]
Dicarbonyl/L-xylulose reductase (DCXR) DME Info Homo sapiens [1]
DOPA decarboxylase (DDC) DME Info Homo sapiens [1]
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [1]
Dihydrofolate reductase (DHFR) DME Info Homo sapiens [1]
Fatty acid desaturase 1 (FADS1) DME Info Homo sapiens [1]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [1]
Glutathione S-transferase mu-1 (GSTM1) DME Info Homo sapiens [2]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [1]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [1], [2]
Ketoacyl-CoA reductase (HSD17B12) DME Info Homo sapiens [1]
Keto-steroid reductase (HSD17B7) DME Info Homo sapiens [1]
Dihydrotestosterone oxidoreductase (HSD3B1) DME Info Homo sapiens [1]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [1]
Methionine-R-sulfoxide reductase B1 (MSRB1) DME Info Homo sapiens [1]
Mevalonate pyrophosphate decarboxylase (MPD) DME Info Homo sapiens [1]
NADH-ubiquinone oxidoreductase 30 kDa (NDUFS3) DME Info Homo sapiens [1]
NADH-ubiquinone oxidoreductase 20 kDa (NDUFS7) DME Info Homo sapiens [1]
Propionyl-CoA carboxylase beta (PCCB) DME Info Homo sapiens [1]
Phosphoglucomutase 1 (PGM1) DME Info Homo sapiens [1]
Serum paraoxonase/lactonase 3 (PON3) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [2]
Steroid 5-alpha-reductase 1 (SRD5A1) DME Info Homo sapiens [1]
Transglutaminase K (TGM1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [3]
Retinoic acid 4-hydroxylase 26B1 (CYP26B1) DME Info Homo sapiens [3], [4]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [5]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [3]
Glutamine synthetase (GLUL) DME Info Homo sapiens [2]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [2]
References
1 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
2 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
3 Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
4 Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo. Br J Cancer. 2007 Jun 4;96(11):1675-83.
5 Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.

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