Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00723)
Xenobiotics Name
(+)-JQ1
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Preclinical/Patented Drug
Structure
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3D MOL 2D MOL
PubChem CID
46907787
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acyl-CoA thioesterase 2 (ACOT2) DME Info Homo sapiens [1], [2]
Tartrate-resistant acid ATPase (ACP5) DME Info Homo sapiens [2]
Adenosine aminohydrolase (ADA) DME Info Homo sapiens [3]
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [3]
Small intestine reductase (AKR1B10) DME Info Homo sapiens [3]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [3]
Aldehyde dehydrogenase 1 (ALDH1) DME Info Homo sapiens [4]
Aldehyde dehydrogenase 5 (ALDHX) DME Info Homo sapiens [1], [5]
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [2]
Aldehyde oxidase (AOX1) DME Info Homo sapiens [1]
Adenine phosphoribosyltransferase (APRT) DME Info Homo sapiens [2]
Arsenite methyltransferase (AS3MT) DME Info Homo sapiens [6]
Bile acid-CoA thioesterase (BAAT) DME Info Homo sapiens [3]
Cytosolic branched aminotransferase (BCAT1) DME Info Homo sapiens [1]
Serine sulfhydrase (CBS) DME Info Homo sapiens [1], [3]
Cytidine aminohydrolase (CDA) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [7]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [3]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [3]
Cytochrome P450 2C18 (CYP2C18) DME Info Homo sapiens [3]
Lauric acid omega-hydroxylase (CYP4A11) DME Info Homo sapiens [8]
DOPA decarboxylase (DDC) DME Info Homo sapiens [3]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [2]
Dipeptidyl peptidase IV (DPP4) DME Info Homo sapiens [2]
Fatty acid desaturase 1 (FADS1) DME Info Homo sapiens [5]
Dimethylaniline oxidase 3 (FMO3) DME Info Homo sapiens [1]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [3]
Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DME Info Homo sapiens [9], [1]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [3]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [10]
Microsomal glutathione S-transferase 2 (MGST2) DME Info Homo sapiens [6]
Neprilysin (MME) DME Info Homo sapiens [1]
Myeloperoxidase (MPO) DME Info Homo sapiens [10]
Metallothionein-1A (MT1A) DME Info Homo sapiens [1], [3]
Methylenetetrahydrofolate reductase (MTHFR) DME Info Homo sapiens [11]
NADH-ubiquinone oxidoreductase 49 kDa (NDUFS2) DME Info Homo sapiens [2]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [3]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [3]
Deoxy-5'-nucleotidase 1 (NT5C) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [7]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [7]
Tryptophan oxygenase (TRPO) DME Info Homo sapiens [1]
Transglutaminase H (TGM2) DME Info Homo sapiens [9], [1]
Transglutaminase E (TGM3) DME Info Homo sapiens [3]
Transglutaminase X (TGM5) DME Info Homo sapiens [3]
Thymidylate synthase (TYMS) DME Info Homo sapiens [7]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2A3 (UGT2A3) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info Homo sapiens [3]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [2]
Xanthine dehydrogenase/oxidase (XDH) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [1]
Aminomuconic semialdehyde dehydrogenase (ALDH12) DME Info Homo sapiens [12]
Arachidonate 15-lipoxygenase (ALOX15) DME Info Homo sapiens [3]
Arylsulfatase A (ARSA) DME Info Homo sapiens [6]
Asparagine synthetase (ASNS) DME Info Homo sapiens [1], [3]
Vitamin D 25-hydroxylase (CYP2R1) DME Info Homo sapiens [1]
Cytochrome P450 4F12 (CYP4F12) DME Info Homo sapiens [3]
Dicarbonyl/L-xylulose reductase (DCXR) DME Info Homo sapiens [3]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [3]
L-glutamine amidohydrolase (GLS) DME Info Homo sapiens [13]
Metallothionein-2A (MT2A) DME Info Homo sapiens [3]
Methylarsonite methyltransferase N6AMT1 (N6AMT1) DME Info Homo sapiens [1]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [14]
Choline phosphatase 1 (PLD1) DME Info Homo sapiens [3]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [3]
Steroid 5-alpha-reductase 1 (SRD5A1) DME Info Homo sapiens [4]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [1]
References
1 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
2 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
3 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
4 Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells. Mol Cancer Ther. 2014 May;13(5):1142-54.
5 BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 2011 Sep 16;146(6):904-17.
6 Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
7 The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models. Oncogene. 2016 Feb 18;35(7):833-45.
8 BET bromodomain inhibition of MYC-amplified medulloblastoma. Clin Cancer Res. 2014 Feb 15;20(4):912-25.
9 PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature. 2014 Oct 9;514(7521):247-51.
10 BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Blood. 2012 Oct 4;120(14):2843-52.
11 BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. Oncotarget. 2013 Nov;4(11):2080-95.
12 Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-beta-dependent mechanisms. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66.
13 Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma. Int J Cancer. 2015 May 1;136(9):2055-64.
14 Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression. J Immunol. 2014 May 15;192(10):4913-4920.

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