Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00919)
Xenobiotics Name
Particulate matter
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Mixture
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [1]
Catalase (CAT) DME Info Homo sapiens [2]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [3]
Adenosine 5'-monophosphoramidase (HINT1) DME Info Homo sapiens [4]
Heparanase (HPSE) DME Info Homo sapiens [5]
Microsomal glutathione S-transferase 2 (MGST2) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [6]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [2]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [7], [8]
DME(s) Induced by This Xenobiotics
Acyl-CoA thioesterase 2 (ACOT2) DME Info Homo sapiens [9]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [9]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [10]
Aldo-keto reductase 1C4 (AKR1C4) DME Info Homo sapiens [11], [12]
Aldehyde dehydrogenase 2 (ALDH2) DME Info Homo sapiens [2]
Arachidonate 12-lipoxygenase (ALOX12B) DME Info Homo sapiens [13]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [14], [15]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [16]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [17]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [18]
Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DME Info Homo sapiens [17]
Monoamine oxidase type B (MAO-B) DME Info Homo sapiens [16]
Metallothionein-1A (MT1A) DME Info Homo sapiens [2]
Metallothionein-2A (MT2A) DME Info Homo sapiens [2]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [2]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [19]
Cytosolic phospholipase A2 (PLA2G4A) DME Info Homo sapiens [1], [20]
Prostaglandin reductase 1 (PTGR1) DME Info Homo sapiens [17]
Transglutaminase E (TGM3) DME Info Homo sapiens [21]
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME Info Homo sapiens [22]
Uracil phosphoribosyltransferase (UPRT) DME Info Homo sapiens [17]
References
1 Changes in differential gene expression in fibroblast cells from patients with triple A syndrome under oxidative stress. Horm Metab Res. 2013 Feb;45(2):102-8.
2 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
3 High-affinity binding of fatty acyl-CoAs and peroxisome proliferator-CoA esters to glutathione S-transferases effect on enzymatic activity. Eur J Biochem. 1999 Nov;266(1):143-50.
4 MnTMPyP inhibits paraquat-induced pulmonary epithelial-like cell injury by inhibiting oxidative stress. J Toxicol Sci. 2018;43(9):545-555.
5 The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: implications for coadministration with clopidogrel. Drug Metab Dispos. 2011 Nov;39(11):2020-33.
6 Human and rodent carboxylesterases: immunorelatedness, overlapping substrate specificity, differential sensitivity to serine enzyme inhibitors, and tumor-related expression. Drug Metab Dispos. 2002 May;30(5):541-7.
7 Brazil nut improves the oxidative metabolism of superoxide-hydrogen peroxide chemically-imbalanced human fibroblasts in a nutrigenomic manner. Food Chem Toxicol. 2018 Nov;121:519-526.
8 Cytotoxicity and gene array analysis of alveolar epithelial A549 cells exposed to paraquat. Chem Biol Interact. 2010 Dec 5;188(3):427-36.
9 Nitric oxide-mediated toxicity in paraquat-exposed SH-SY5Y cells: a protective role of 7-nitroindazole. Neurotox Res. 2009 Aug;16(2):160-73.
10 Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin. J Lipid Res. 2008 Oct;49(10):2142-8.
11 SODs are involved in the regulation of ICAM-1 expression in human melanoma and endothelial cells. Cell Mol Biol (Noisy-le-grand). 1999 Nov;45(7):1053-63.
12 Age-dependent basal level and induction capacity of copper-zinc and manganese superoxide dismutase and other scavenging enzyme activities in leukocytes from young and elderly adults. Am J Pathol. 1993 Jul;143(1):312-20.
13 Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes. Toxicol Lett. 2015 Oct 1;238(1):43-53.
14 Palmatine activates AhR and upregulates CYP1A activity in HepG2 cells but not in human hepatocytes. Toxicol In Vitro. 2014 Jun;28(4):693-9.
15 Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces hepatic steatosis and endoplasmic reticulum stress by inducing nuclear factor erythroid-derived 2-related factor 2 nuclear translocation. Toxicol Appl Pharmacol. 2018 Dec 1;360:18-29.
16 Oxidative stress induced by palytoxin in human keratinocytes is mediated by a H+-dependent mitochondrial pathway. Toxicol Appl Pharmacol. 2013 Jan 1;266(1):1-8.
17 Human drug metabolism genes in parathion-and estrogen-treated breast cells. Int J Mol Med. 2007 Dec;20(6):875-81.
18 Cytoprotective effect of bioactive sea buckthorn extract on paraquat-exposed A549 cells via induction of Nrf2 and its downstream genes. Mol Med Rep. 2013 Dec;8(6):1852-60.
19 An evaluation of the cytochrome P450 induction potential of pantoprazole in primary human hepatocytes. Chem Biol Interact. 1998 Jul 3;114(1-2):1-13.
20 Paraquat induces cyclooxygenase-2 (COX-2) implicated toxicity in human neuroblastoma SH-SY5Y cells. Toxicol Lett. 2010 Dec 15;199(3):239-46.
21 Nrf2/ARE pathway involved in oxidative stress induced by paraquat in human neural progenitor cells. Oxid Med Cell Longev. 2016;2016:8923860.
22 Pamidronate increases markers of bone formation in patients with multiple myeloma in plateau phase under interferon-alpha treatment. Calcif Tissue Int. 2001 May;68(5):285-90.

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