Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01253)
Xenobiotics Name
Cinnamic aldehyde
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Product
Structure
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3D MOL 2D MOL
PubChem CID
637511
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Ampc beta-lactamase (ampC) DME Info Burkholderia cenocepacia [1]
AmpC beta-lactamase (ampC) DME Info Burkholderia multivorans [1]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [2]
Insulin-degrading enzyme (ide) DME Info Vibrio vulnificus [3]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [4]
Beta-lactamase (blaB) DME Info Burkholderia multivorans [1]
Beta-lactamase (blaB) DME Info Burkholderia cenocepacia [1]
DME(s) Induced by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [5]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [6]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [6]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [5]
Glutathione reductase (GSR) DME Info Homo sapiens [7]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [8]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [7]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [5]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [9]
References
1 Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia. Res Microbiol. 2009 Mar;160(2):144-51.
2 Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1. Chem Biol Interact. 1997 Dec 12;108(1-2):67-78.
3 Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio sppby decreasing the DNA-binding activity of the quorum sensing response regulator LuxR. BMC Microbiol. 2008 Sep 16;8:149.
4 Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus. Appl Microbiol Biotechnol. 2014 Nov;98(22):9447-57.
5 The THP-1 cell toolbox: a new concept integrating the key events of skin sensitization. Arch Toxicol. 2019 Apr;93(4):941-951.
6 Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde. Toxicol Appl Pharmacol. 2009 Sep 15;239(3):273-83.
7 The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth. Free Radic Biol Med. 2009 Jan 15;46(2):220-31.
8 Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress. Free Radic Biol Med. 2008 Aug 15;45(4):385-95.
9 Cinnamaldehyde inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: effects upon IkappaB and Nrf2. Toxicol Appl Pharmacol. 2008 Jun 1;229(2):161-71.

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