Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01304)
Xenobiotics Name
Flavone
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Product
Structure
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3D MOL 2D MOL
PubChem CID
10680
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Azoreductase (azoR) DME Info Escherichia coli [1]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [1]
Beta-lactamase (blaB) DME Info Escherichia coli [1]
Chloramphenicolase (chlR) DME Info Escherichia coli [1]
Glycoside hydrolase (cscA) DME Info Escherichia coli [1]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [3]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [1]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [1]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [1]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [4]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [1]
Glutamate racemase (MurI) DME Info Escherichia coli [1]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [1]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [1]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [1]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [1]
Tyramine oxidase (tynA) DME Info Escherichia coli [1]
Beta-glucuronidase (uidA) DME Info Escherichia coli [1]
DME(s) Induced by This Xenobiotics
Aromatase (CYP19A1) DME Info Homo sapiens [5]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [6]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 1B1 (CYP1B1) DME Info IC50 = 0.6 microM [3]
References
1 Apple flavonoid phloretin inhibits Escherichia coli O157:H7 biofilm formation and ameliorates colon inflammation in rats. Infect Immun. 2011 Dec;79(12):4819-27.
2 Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Chem Res Toxicol. 2010 Dec 20;23(12):1921-35.
3 Inhibitors of cytochrome P450 (CYP) 1B1. Eur J Med Chem. 2017 Jul 28;135:296-306.
4 Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria. J Agric Food Chem. 2012 Oct 17;60(41):10270-7.
5 Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci. 2004 Nov;82(1):70-9.
6 Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. Mol Cell Biol. 2004 Jun;24(12):5209-22.

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