Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01512)
Xenobiotics Name
Zinc
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Environmental Pollutant
Structure
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3D MOL 2D MOL
PubChem CID
23994
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Azoreductase (azoR) DME Info Escherichia coli [1]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [1]
Beta-lactamase (blaB) DME Info Escherichia coli [1]
Catalase (CAT) DME Info Homo sapiens [2]
Chloramphenicolase (chlR) DME Info Escherichia coli [1]
Glycoside hydrolase (cscA) DME Info Escherichia coli [1]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [1]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [1]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [1]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [1]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [1]
Glutamate racemase (MurI) DME Info Escherichia coli [1]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [1]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [1]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [1]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [1]
Tyramine oxidase (tynA) DME Info Escherichia coli [1]
Beta-glucuronidase (uidA) DME Info Escherichia coli [1]
DME(s) Induced by This Xenobiotics
Alcohol dehydrogenase class-V (ADH6) DME Info Homo sapiens [3]
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [2]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [4]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [5]
Cytochrome P450 2F1 (CYP2F1) DME Info Homo sapiens [6]
Metallothionein-2A (MT2A) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [2]
Thymidylate synthase (TYMS) DME Info Homo sapiens [7]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info Homo sapiens [3]
References
1 The micronutrient zinc inhibits EAEC strain 042 adherence, biofilm formation, virulence gene expression, and epithelial cytokine responses benefiting the infected host. Virulence. 2013 Oct 1;4(7):624-33.
2 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
3 Vitamin D protects against particles-caused lung injury through induction of autophagy in an Nrf2-dependent manner. Environ Toxicol. 2019 May;34(5):594-609.
4 Lithocholic acid downregulates vitamin D effects in human osteoblasts. Eur J Clin Invest. 2010 Jan;40(1):25-34.
5 Rapid and drastic induction of CYP3A4 mRNA expression via vitamin D receptor in human intestinal LS180 cells. Drug Metab Pharmacokinet. 2007 Oct;22(5):377-81.
6 Dynamic and ligand-selective interactions of vitamin D receptor with retinoid X receptor and cofactors in living cells. Mol Pharmacol. 2011 Dec;80(6):1147-55.
7 Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.

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