Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0005)
DME Name Cytochrome P450 2A6 (CYP2A6), Homo sapiens DME Info
UniProt ID
CP2A6_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium adolescentis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bifidobacterium adolescentis co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium breve (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bifidobacterium breve co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium longum (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bifidobacterium longum co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bifidobacterium longum co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bifidobacterium ruminatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bifidobacterium ruminatum co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bifidobacterium ruminatum co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Collinsella aerofaciens (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Zidovudine Click to Show/Hide the Detail
                                 Drug ID DR1729   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Collinsella aerofaciens co-metabolize the drug Zidovudine, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Collinsella intestinalis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Collinsella intestinalis co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Eggerthella lenta (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Eggerthella lenta co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Bacteroidetes
                  Alistipes indistinctus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Alistipes indistinctus co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Alistipes indistinctus co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Alistipes indistinctus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Alistipes indistinctus co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides caccae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides caccae co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                  Bacteroides cellulosilyticus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides cellulosilyticus co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides cellulosilyticus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides cellulosilyticus co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides coprophilus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides coprophilus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides dorei co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Methoxsalen Click to Show/Hide the Detail
                                 Drug ID DR1047   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides dorei co-metabolize the drug Methoxsalen, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides dorei co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides dorei co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides eggerthii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides eggerthii co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Methoxsalen Click to Show/Hide the Detail
                                 Drug ID DR1047   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides eggerthii co-metabolize the drug Methoxsalen, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides eggerthii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides eggerthii co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides finegoldii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides finegoldii co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Methoxsalen Click to Show/Hide the Detail
                                 Drug ID DR1047   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides finegoldii co-metabolize the drug Methoxsalen, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides finegoldii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides finegoldii co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides fragilis co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides fragilis co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Methoxsalen Click to Show/Hide the Detail
                                 Drug ID DR1047   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides fragilis co-metabolize the drug Methoxsalen, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides fragilis co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [8], [9]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides fragilis co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides fragilis co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides intestinalis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides intestinalis co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides intestinalis co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides intestinalis co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides ovatus co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides ovatus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides ovatus co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides sartorii co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Methoxsalen Click to Show/Hide the Detail
                                 Drug ID DR1047   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides sartorii co-metabolize the drug Methoxsalen, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides sartorii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides sartorii co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides stercoris co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides stercoris co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides stercoris co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides thetaiotaomicron co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides thetaiotaomicron co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides thetaiotaomicron co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides uniformis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides uniformis co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides uniformis co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides uniformis co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides vulgatus co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides vulgatus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides vulgatus co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides xylanisolvens co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Methoxsalen Click to Show/Hide the Detail
                                 Drug ID DR1047   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides xylanisolvens co-metabolize the drug Methoxsalen, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides xylanisolvens co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides xylanisolvens co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Odoribacter splanchnicus co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Methoxsalen Click to Show/Hide the Detail
                                 Drug ID DR1047   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Odoribacter splanchnicus co-metabolize the drug Methoxsalen, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Odoribacter splanchnicus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Odoribacter splanchnicus co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Parabacteroides distasonis co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Methoxsalen Click to Show/Hide the Detail
                                 Drug ID DR1047   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Parabacteroides distasonis co-metabolize the drug Methoxsalen, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Parabacteroides distasonis co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Parabacteroides johnsonii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Parabacteroides johnsonii co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Methoxsalen Click to Show/Hide the Detail
                                 Drug ID DR1047   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Parabacteroides johnsonii co-metabolize the drug Methoxsalen, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Parabacteroides johnsonii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Parabacteroides johnsonii co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Parabacteroides merdae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Parabacteroides merdae co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Parabacteroides merdae co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Parabacteroides merdae co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Prevotella copri co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Prevotella copri co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Prevotella copri co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Anaerobutyricum hallii co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Anaerococcus hydrogenalis (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Anaerococcus hydrogenalis co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Zidovudine Click to Show/Hide the Detail
                                 Drug ID DR1729   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Anaerococcus hydrogenalis co-metabolize the drug Zidovudine, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Anaerostipes hadrus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Anaerostipes hadrus co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Anaerotruncus colihominis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Anaerotruncus colihominis co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacillus megaterium co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [11]
                              Chlorzoxazone Click to Show/Hide the Detail
                                 Drug ID DR0312   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacillus megaterium co-metabolize the drug Chlorzoxazone, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [13], [11]
                              Progesterone Click to Show/Hide the Detail
                                 Drug ID DR1346   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacillus megaterium co-metabolize the drug Progesterone, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [14]
                  Bacteroides pectinophilus (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides pectinophilus co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Bacteroides pectinophilus co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Blautia hansenii co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Blautia hansenii co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Methoxsalen Click to Show/Hide the Detail
                                 Drug ID DR1047   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Blautia hansenii co-metabolize the drug Methoxsalen, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Nevirapine Click to Show/Hide the Detail
                                 Drug ID DR1142   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Blautia hansenii co-metabolize the drug Nevirapine, which can collectively affect efficacy, safety or bioavailability of this drug. [15], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Blautia hansenii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                  Blautia luti (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Blautia luti co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridioides difficile (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Clostridioides difficile co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [16]
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Clostridioides difficile co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Clostridium botulinum co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Nevirapine Click to Show/Hide the Detail
                                 Drug ID DR1142   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Clostridium botulinum co-metabolize the drug Nevirapine, which can collectively affect efficacy, safety or bioavailability of this drug. [15], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Clostridium botulinum co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                  Clostridium perfringens (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Clostridium perfringens co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [17]
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Clostridium perfringens co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [17]
                  Clostridium scindens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Clostridium scindens co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium spiroforme (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Clostridium spiroforme co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium sporogenes (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Clostridium sporogenes co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Methoxsalen Click to Show/Hide the Detail
                                 Drug ID DR1047   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Clostridium sporogenes co-metabolize the drug Methoxsalen, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium symbiosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Clostridium symbiosum co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Coprococcus comes (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Coprococcus comes co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Dorea formicigenerans (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Dorea formicigenerans co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterocloster asparagiformis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Enterocloster asparagiformis co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterocloster bolteae (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Enterocloster bolteae co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterococcus casseliflavus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Enterococcus casseliflavus co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [18]
                  Enterococcus faecalis (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Enterococcus faecalis co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [16]
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Enterococcus faecalis co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterococcus gallinarum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Enterococcus gallinarum co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [18]
                  Erysipelatoclostridium ramosum (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Erysipelatoclostridium ramosum co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Methoxsalen Click to Show/Hide the Detail
                                 Drug ID DR1047   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Erysipelatoclostridium ramosum co-metabolize the drug Methoxsalen, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Eubacterium rectale (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Eubacterium rectale co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Eubacterium ventriosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Eubacterium ventriosum co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Holdemanella biformis (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Holdemanella biformis co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Holdemanella biformis co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Holdemanella biformis co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                  Hungatella hathewayi (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Hungatella hathewayi co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Hungatella hathewayi co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                  Lactobacillus johnsonii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Tegafur Click to Show/Hide the Detail
                                 Drug ID DR1539   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Lactobacillus johnsonii co-metabolize the drug Tegafur, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [20]
                  Lactobacillus reuteri (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Lactobacillus reuteri co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Marvinbryantia formatexigens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Marvinbryantia formatexigens co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Roseburia intestinalis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Roseburia intestinalis co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Ruminococcus gnavus (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Ruminococcus gnavus co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Ruminococcus gnavus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                  Ruminococcus lactaris (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Ruminococcus lactaris co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Ruminococcus torques (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Ruminococcus torques co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Ruminococcus torques co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                  Subdoligranulum variabile (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Subdoligranulum variabile co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Subdoligranulum variabile co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
      Bacteria: Lentisphaerae
                  Victivallis vadensis (PVC bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Victivallis vadensis co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Victivallis vadensis co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
      Bacteria: Proteobacteria
                  Citrobacter freundii (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Citrobacter freundii co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [16]
                  Edwardsiella tarda (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Edwardsiella tarda co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterobacter cancerogenus (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Enterobacter cancerogenus co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterobacter cloacae (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Enterobacter cloacae co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [21]
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Escherichia coli co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [16]
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Escherichia coli co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Flunitrazepam Click to Show/Hide the Detail
                                 Drug ID DR0712   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Escherichia coli co-metabolize the drug Flunitrazepam, which can collectively affect efficacy, safety or bioavailability of this drug. [22], [23]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Escherichia coli co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Escherichia coli co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Novosphingobium aromaticivorans (alpha-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              BRN-1907611 Click to Show/Hide the Detail
                                 Drug ID DR2268   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Novosphingobium aromaticivorans co-metabolize the drug BRN-1907611, which can collectively affect efficacy, safety or bioavailability of this drug. [24], [25], [26]
                  Proteus penneri (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Proteus penneri co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Providencia alcalifaciens (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Providencia alcalifaciens co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Providencia alcalifaciens co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Providencia rettgeri (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Providencia rettgeri co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Providencia stuartii (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Providencia stuartii co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Providencia stuartii co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Pseudomonas furukawaii (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Flavone Click to Show/Hide the Detail
                                 Drug ID DR2144   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Pseudomonas furukawaii co-metabolize the drug Flavone, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [28]
                  Pseudomonas putida (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Nicotine Click to Show/Hide the Detail
                                 Drug ID DR1148   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Pseudomonas putida co-metabolize the drug Nicotine, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [30]
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Salmonella enterica co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Roxatidine Click to Show/Hide the Detail
                                 Drug ID DR1447   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Salmonella enterica co-metabolize the drug Roxatidine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
      Bacteria: Verrucomicrobia
                  Akkermansia muciniphila (verrucomicrobiae) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Artemisinin Click to Show/Hide the Detail
                                 Drug ID DR0141   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Akkermansia muciniphila co-metabolize the drug Artemisinin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Fungi: Ascomycota
                  Saccharomyces cerevisiae (ascomycota) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) metabolizes the drug Acetaminophen, and Saccharomyces cerevisiae further metabolizes its metabolite (1-Phenyl-1,2-propanedione), which can indirectly affect efficacy, safety or bioavailability of this drug. [10], [16]
      Amoebozoa: Evosea
                  Entamoeba histolytica (eukaryotes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Entamoeba histolytica co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [31]
      Metamonada: Fornicata
                  Giardia intestinalis (diplomonads) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Giardia intestinalis co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [31]
      Metamonada: Parabasalia
                  Trichomonas vaginalis (trichomonads) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2A6 (CYP2A6) and Trichomonas vaginalis co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [31]
References
1 Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin. Br J Clin Pharmacol. 1999 Oct;48(4):528-35.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Cytochrome P450 enzymes involved in the metabolic pathway of the histamine 2 (H2)-receptor antagonist roxatidine acetate by human liver microsomes. Arzneimittelforschung. 2001;51(8):651-8.
4 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
5 Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66.
6 Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66.
7 The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst. Drug Metab Dispos. 2013 Sep;41(9):1686-94.
8 Isolation of metronidazole-resistant Bacteroides fragilis carrying the nimA nitroreductase gene from a patient in Washington State. J Clin Microbiol. 2004 Sep;42(9):4127-9. Case Reports
9 Biotransformation of 1-nitropyrene in intestinal anaerobic bacteria. Microbiol Immunol. 1982;26(11):993-1005.
10 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
11 The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.
12 Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes. Drug Metab Dispos. 1999 Nov;27(11):1274-80.
13 Wild-type CYP102A1 as a biocatalyst: turnover of drugs usually metabolised by human liver enzymes. J Biol Inorg Chem. 2007 Mar;12(3):313-23.
14 acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.
15 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
16 Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018 Jul;69(1):51-59.
17 Acetamide--a metabolite of metronidazole formed by the intestinal flora. Biochem Pharmacol. 1979 Dec 15;28(24):3611-5.
18 Mechanism of metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. FEMS Microbiol Lett. 2003 Aug 29;225(2):195-200.
19 Rapid development of S-1 in the west for therapy of advanced gastric carcinoma. Gan To Kagaku Ryoho. 2006 Jun;33 Suppl 1:117-20.
20 Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria. J Control Release. 2016 Jan 28;222:9-17.
21 Overexpression, isotopic labeling, and spectral characterization of Enterobacter cloacae nitroreductase. Protein Expr Purif. 1998 Jun;13(1):53-60.
22 CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam. Drug Metab Dispos. 2001 Feb;29(2):133-40.
23 Structure-based development of bacterial nitroreductase against nitrobenzodiazepine-induced hypnosis. Biochem Pharmacol. 2012 Jun 15;83(12):1690-9.
24 In vitro metabolism of (-)-camphor using human liver microsomes and CYP2A6. Biol Pharm Bull. 2007 Feb;30(2):230-3.
25 Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov;38(5):1250-7.
26 A cytochrome P450 class I electron transfer system from Novosphingobium aromaticivorans. Appl Microbiol Biotechnol. 2010 Mar;86(1):163-75.
27 Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes. Xenobiotica. 2019 Jul;49(7):791-802.
28 Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. Appl Microbiol Biotechnol. 2011 Jul;91(2):219-28.
29 CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine delta-5'(1')iminium ion. J Pharmacol Exp Ther. 2012 Nov;343(2):307-15.
30 Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction. BMC Biotechnol. 2019 Aug 2;19(1):56.
31 Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). Antimicrob Agents Chemother. 2009 Feb;53(2):458-64.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.