Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0080)
DME Name Cytidine aminohydrolase (CDA), Homo sapiens DME Info
UniProt ID
CDD_HUMAN
EC Number    EC: 3.5.4.5     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amidine hydrolase
EC: 3.5.4.5
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Collinsella aerofaciens (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Capecitabine Click to Show/Hide the Detail
                                 Drug ID DR0266   Drug Info
                                 Interaction Mechanism Human Cytidine aminohydrolase (CDA) and Collinsella aerofaciens co-metabolize the drug Capecitabine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Gemcitabine Click to Show/Hide the Detail
                                 Drug ID DR0765   Drug Info
                                 Interaction Mechanism Human Cytidine aminohydrolase (CDA) and Escherichia coli co-metabolize the drug Gemcitabine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Klebsiella pneumoniae (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Gemcitabine Click to Show/Hide the Detail
                                 Drug ID DR0765   Drug Info
                                 Interaction Mechanism Human Cytidine aminohydrolase (CDA) and Klebsiella pneumoniae co-metabolize the drug Gemcitabine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Capecitabine Click to Show/Hide the Detail
                                 Drug ID DR0266   Drug Info
                                 Interaction Mechanism Human Cytidine aminohydrolase (CDA) and Salmonella enterica co-metabolize the drug Capecitabine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Tenericutes
                  Mycoplasma hyorhinis (mycoplasmas) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Azacitidine Click to Show/Hide the Detail
                                 Drug ID DR0163   Drug Info
                                 Interaction Mechanism Human Cytidine aminohydrolase (CDA) and Mycoplasma hyorhinis co-metabolize the drug Azacitidine, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [6]
                              Cytarabine Click to Show/Hide the Detail
                                 Drug ID DR0398   Drug Info
                                 Interaction Mechanism Human Cytidine aminohydrolase (CDA) and Mycoplasma hyorhinis co-metabolize the drug Cytarabine, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [6]
                              Decitabine Click to Show/Hide the Detail
                                 Drug ID DR1763   Drug Info
                                 Interaction Mechanism Human Cytidine aminohydrolase (CDA) and Mycoplasma hyorhinis co-metabolize the drug Decitabine, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [6]
                              Gemcitabine Click to Show/Hide the Detail
                                 Drug ID DR0765   Drug Info
                                 Interaction Mechanism Human Cytidine aminohydrolase (CDA) and Mycoplasma hyorhinis co-metabolize the drug Gemcitabine, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [6]
References
1 Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. Int J Cancer. 2003 Sep 20;106(5):799-805.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Equilibrative nucleoside transporter 1 genotype, cytidine deaminase activity and age predict gemcitabine plasma clearance in patients with solid tumours. Br J Clin Pharmacol. 2011 Mar;71(3):437-44.
4 Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 Sep 15;357(6356):1156-1160.
5 A pilot pharmacokinetic study of oral azacitidine. Leukemia. 2008 Sep;22(9):1680-4.
6 Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9.
7 Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74.
8 Tracking decitabine incorporation into malignant myeloid cell DNA in vitro and in vivo by LC-MS/MS with enzymatic digestion. Sci Rep. 2019 Mar 14;9(1):4558.

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