Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0063)
DME Name Sulfotransferase 1A3 (SULT1A3), Homo sapiens DME Info
UniProt ID
ST1A3_HUMAN
EC Number    EC: 2.8.2.1     (Click to Show/Hide the Complete EC Tree)
Transferase
Sulfotransferase
Sulfotransferase
EC: 2.8.2.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Health or Environmental Toxicant(s)
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene up-regulates the expression of DME SULT1A3 [1]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Diethylhexyl phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate up-regulates the expression of DME SULT1A3 [2]
                              Glycidamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01009   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Glycidamide up-regulates the expression of DME SULT1A3 [3]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Amiodarone hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00277   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amiodarone hydrochloride up-regulates the expression of DME SULT1A3 [4]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Ethanol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00539   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ethanol inhibits the drug-metabolizing activity of DME SULT1A3 [5]
References
1 Benzo[a]pyrene and glycine N-methyltransferse interactions: gene expression profiles of the liver detoxification pathway. Toxicol Appl Pharmacol. 2006 Jul 15;214(2):126-35.
2 Long-term di (2-ethylhexyl)-phthalate exposure promotes proliferation and survival of HepG2 cells via activation of NFB. Toxicol In Vitro. 2017 Aug;42:86-92.
3 Expression profile of human cells in culture exposed to glycidamide, a reactive metabolite of the heat-induced food carcinogen acrylamide. Toxicology. 2007 Oct 30;240(1-2):111-24.
4 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
5 Solvent effect on cDNA-expressed human sulfotransferase (SULT) activities in vitro. Drug Metab Dispos. 2003 Nov;31(11):1300-5.

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