Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01004)
Xenobiotics Name
Diethylhexyl phthalate
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Health Hazard/Toxicant
Structure
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3D MOL 2D MOL
PubChem CID
8343
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acetyl-CoA synthetase (ACSS2) DME Info Homo sapiens [1]
Aldehyde oxidase (AOX1) DME Info Homo sapiens [1]
Arylsulfatase A (ARSA) DME Info Homo sapiens [1]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [1]
Beta,beta-carotene 15,15'-dioxygenase (BCO1) DME Info Homo sapiens [1]
Steroid 11-beta-hydroxylase (CYP11B1) DME Info Homo sapiens [1]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [1]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [1]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [1]
Cytochrome P450 2F1 (CYP2F1) DME Info Homo sapiens [1]
Cytochrome P450 2J2 (CYP2J2) DME Info Homo sapiens [2]
Cytochrome P450 3A43 (CYP3A43) DME Info Homo sapiens [1]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [1]
Cholesterol 24-hydroxylase (CYP46A1) DME Info Homo sapiens [1]
Bifunctional epoxide hydrolase 2 (EPHX2) DME Info Homo sapiens [1]
Glutathione S-transferase omega-2 (GSTO2) DME Info Homo sapiens [1]
Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DME Info Homo sapiens [1]
Dihydrotestosterone oxidoreductase (HSD3B1) DME Info Homo sapiens [1]
Indoleamine 2,3-dioxygenase 1 (IDO1) DME Info Homo sapiens [1]
Monoamine oxidase type B (MAO-B) DME Info Homo sapiens [1]
Neprilysin (MME) DME Info Homo sapiens [1]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [1]
Nitric oxide synthase brain (NOS1) DME Info Homo sapiens [1]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [1]
Choline phosphatase 1 (PLD1) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [3]
Transglutaminase H (TGM2) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [2]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [2]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [2]
Aldehyde dehydrogenase 1 (ALDH1) DME Info Homo sapiens [1]
Alkaline phosphatase (ALPL) DME Info Homo sapiens [1]
Catalase (CAT) DME Info Homo sapiens [4]
NADPH-dependent carbonyl reductase 3 (CBR3) DME Info Homo sapiens [1]
Catechol O-methyltransferase (COMT) DME Info Homo sapiens [1]
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [5]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [6]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [7]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [2]
Glutathione S-transferase alpha-2 (GSTA2) DME Info Homo sapiens [2]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [1]
Histamine N-methyltransferase (HNMT) DME Info Homo sapiens [1]
Estradiol 17-beta-dehydrogenase 1 (HSD17B1) DME Info Homo sapiens [1]
Keto-steroid reductase (HSD17B7) DME Info Homo sapiens [1]
Microsomal glutathione S-transferase 2 (MGST2) DME Info Homo sapiens [1]
Metallothionein-2A (MT2A) DME Info Homo sapiens [1]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [1]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [1]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [1]
Sulfotransferase 1A3 (SULT1A3) DME Info Homo sapiens [2]
Transglutaminase K (TGM1) DME Info Homo sapiens [1]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [1]
References
1 Di-(2-ethylhexyl)-phthalate induces apoptosis via the PPARgama/PTEN/AKT pathway in differentiated human embryonic stem cells. Food Chem Toxicol. 2019 Sep;131:110552.
2 Long-term di (2-ethylhexyl)-phthalate exposure promotes proliferation and survival of HepG2 cells via activation of NFB. Toxicol In Vitro. 2017 Aug;42:86-92.
3 Histone deacetylase 4 promotes ubiquitin-dependent proteasomal degradation of Sp3 in SH-SY5Y cells treated with di(2-ethylhexyl)phthalate (DEHP), determining neuronal death. Toxicol Appl Pharmacol. 2014 Oct 1;280(1):190-8.
4 Di (2-ethylhexyl) phthalate induces cytotoxicity in HEK-293 cell line, implication of the Nrf-2/HO-1 antioxidant pathway. Environ Toxicol. 2019 Sep;34(9):1034-1042.
5 Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver. Crit Rev Toxicol. 2006 May;36(5):459-79.
6 An in vivo bioassay for detecting antiandrogens using humanized transgenic mice coexpressing the tetracycline-controlled transactivator and human CYP1B1 gene. Int J Toxicol. 2005 May-Jun;24(3):157-64.
7 Acetyl tributyl citrate, the most widely used phthalate substitute plasticizer, induces cytochrome p450 3a through steroid and xenobiotic receptor. Toxicol Sci. 2011 Oct;123(2):460-70.

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