Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00539)
Xenobiotics Name
Ethanol
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
702
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-III (ADH5) DME Info Homo sapiens [1]
Alkaline phosphatase (ALPL) DME Info Homo sapiens [2]
Catalase (CAT) DME Info Homo sapiens [3]
Serine sulfhydrase (CBS) DME Info Homo sapiens [4]
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [5]
Steroid 11-beta-hydroxylase (CYP11B1) DME Info Homo sapiens [5]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [6]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [6]
Cytochrome P450 4F2 (CYP4F2) DME Info Homo sapiens [7]
Dihydrofolate reductase (DHFR) DME Info Homo sapiens [4]
Glutathione reductase (GSR) DME Info Homo sapiens [8]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [9]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [10]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [11]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [12]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [1]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [2]
Sulfotransferase 1A1 (SULT1A1) DME Info Homo sapiens [13]
Sulfotransferase 1A3 (SULT1A3) DME Info Homo sapiens [13]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [13]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [13]
UDP-glucuronosyltransferase 2A3 (UGT2A3) DME Info Homo sapiens [6]
DME(s) Induced by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [14]
Alcohol dehydrogenase class-I alpha (ADH1A) DME Info Homo sapiens [15]
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [16]
Alcohol dehydrogenase class-I gamma (ADH1C) DME Info Homo sapiens [15]
Aldehyde dehydrogenase 2 (ALDH2) DME Info Homo sapiens [16]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [17]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [18]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [19]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [20]
Cytochrome P450 4F12 (CYP4F12) DME Info Homo sapiens [7]
Dicarbonyl/L-xylulose reductase (DCXR) DME Info Homo sapiens [4]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [21]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [22]
Transglutaminase H (TGM2) DME Info Homo sapiens [23]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [4]
Xanthine dehydrogenase/oxidase (XDH) DME Info Homo sapiens [21]
References
1 Interactive effects of in vitro binge-like alcohol and ATP on umbilical endothelial nitric oxide synthase post-translational modifications and redox modulation. Reprod Toxicol. 2014 Jan;43:94-101.
2 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
3 Gastroprotective effect of gamma-aminobutyric acid against ethanol-induced gastric mucosal injury. Chem Biol Interact. 2017 Jun 25;272:125-134.
4 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
5 Autophagy as a compensation mechanism participates in ethanol-induced fetal adrenal dysfunction in female rats. Toxicol Appl Pharmacol. 2018 Apr 15;345:36-47.
6 Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
7 CYP4F2 repression and a modified alpha-tocopherol (vitamin E) metabolism are two independent consequences of ethanol toxicity in human hepatocytes. Toxicol In Vitro. 2017 Apr;40:124-133.
8 Flavonoid composition of orange peel extract ameliorates alcohol-induced tight junction dysfunction in Caco-2 monolayer. Food Chem Toxicol. 2017 Jul;105:398-406.
9 Alcohol depletes coenzyme-Q(10) associated with increased TNF-alpha secretion to induce cytotoxicity in HepG2 cells. Toxicology. 2012 Dec 8;302(1):34-9.
10 cAMP/PKA/EGR1 signaling mediates the molecular mechanism of ethanol-induced inhibition of placental 11beta-HSD2 expression. Toxicol Appl Pharmacol. 2018 Aug 1;352:77-86.
11 Monoamine oxidase inhibitory activity in tobacco particulate matter: Are harman and norharman the only physiologically relevant inhibitors? Neurotoxicology. 2017 Mar;59:22-26.
12 Ethanol inhibits methionine adenosyltransferase II activity and S-adenosylmethionine biosynthesis and enhances caspase-3-dependent cell death in T lymphocytes: relevance to alcohol-induced immunosuppression. J Nutr Biochem. 2008 Jun;19(6):384-91.
13 Solvent effect on cDNA-expressed human sulfotransferase (SULT) activities in vitro. Drug Metab Dispos. 2003 Nov;31(11):1300-5.
14 Study of acetylcholinesterase activity and apoptosis in SH-SY5Y cells and mice exposed to ethanol. Toxicology. 2017 Jun 1;384:33-39.
15 An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells. Toxicol Sci. 2013 Mar;132(1):131-41.
16 Differences in the activities of resveratrol and ascorbic acid in protection of ethanol-induced oxidative DNA damage in human peripheral lymphocytes. Food Chem Toxicol. 2012 Feb;50(2):168-74.
17 Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathway. PLoS One. 2012;7(4):e35505.
18 beta-Naphtoflavone and ethanol induce cytochrome P450 and protect towards MPP+ toxicity in human neuroblastoma SH-SY5Y cells. Int J Mol Sci. 2018 Oct 28;19(11).
19 Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicol Sci. 2012 Aug;128(2):427-38.
20 Iron-mediated effect of alcohol on hepatocyte differentiation in HepaRG cells. Chem Biol Interact. 2013 Nov 25;206(2):117-25.
21 Mechanism of alcohol-induced oxidative stress and neuronal injury. Free Radic Biol Med. 2008 Dec 1;45(11):1542-50.
22 Ethanol enhances arsenic-induced cyclooxygenase-2 expression via both NFAT and NF-B signalings in colorectal cancer cells. Toxicol Appl Pharmacol. 2015 Oct 15;288(2):232-9.
23 NF-kappaB-activated tissue transglutaminase is involved in ethanol-induced hepatic injury and the possible role of propolis in preventing fibrogenesis. Toxicology. 2008 Apr 18;246(2-3):148-57.

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