Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1094)
DME Name	Beta-lactamase (blaB), Citrobacter freundii	DME Info
UniProt ID	AMPC_CITFR
EC Number	EC: 3.5.2.6 (Click to Show/Hide the Complete EC Tree) Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Citrobacter freundii (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Citrobacter Species: Citrobacter freundii Subspecies: Citrobacter freundii ATCC 6879
Interactome

Interactions between Xenobiotics and DME (XEOTIC)
Amino Acid(s), Peptide(s) or Protein(s)
Peptide		Click to Show/Hide the Full List of Xenobiotics: 8 Xenobiotics
Armadillidin glyc-rich		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02319 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Armadillidin glyc-rich inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Citrobacter freundii				[1]
Bacteriocin L-1077		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02378 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bacteriocin L-1077 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Citrobacter freundii (MIC = 0.76 ug/ml)				[2]
Enterocin E-760		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03253 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Enterocin E-760 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Citrobacter freundii (MIC = 1.6 ug/ml)				[3]
Hydramacin Hm-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03609 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Hydramacin Hm-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Citrobacter freundii				[4], [5]
Leptoglycin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03853 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Leptoglycin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Citrobacter freundii (MIC = 75 microM)				[6]
Magainin-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03985 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Magainin-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Citrobacter freundii (MIC = 30 ug/ml)				[7], [8]
Pilosulin Myr b I		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04606 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Pilosulin Myr b I inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Citrobacter freundii (MIC = 2 microM)				[9]
Pilosulin P1(1-20)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04426 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Pilosulin P1(1-20) inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Citrobacter freundii (MIC = 2 microM)				[10]
Pharmaceutical Agent(s)
Drug in Phase 3 Clinical Trial		Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
Curcumin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00683 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 3
DME Modulation	Curcumin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Citrobacter freundii				[11]
Epigallocatechin gallate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00613 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 3
DME Modulation	Epigallocatechin gallate inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Citrobacter freundii				[11]

References
1	Armadillidin: a novel glycine-rich antibacterial peptide directed against gram-positive bacteria in the woodlouse Armadillidium vulgare (Terrestrial Isopod, Crustacean). Dev Comp Immunol. 2005;29(6):489-99.
2	Isolation of Lactobacillus salivarius 1077 (NRRL B-50053) and characterization of its bacteriocin, including the antimicrobial activity spectrum. Appl Environ Microbiol. 2011 Apr;77(8):2749-54.
3	Isolation and purification of enterocin E-760 with broad antimicrobial activity against gram-positive and gram-negative bacteria. Antimicrob Agents Chemother. 2008 Mar;52(3):1094-100.
4	Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence. Dev Comp Immunol. 2009 Apr;33(4):559-69.
5	Hydramacin-1, structure and antibacterial activity of a protein from the basal metazoan Hydra. J Biol Chem. 2009 Jan 16;284(3):1896-905.
6	Leptoglycin: a new Glycine/Leucine-rich antimicrobial peptide isolated from the skin secretion of the South American frog Leptodactylus pentadactylus (Leptodactylidae). Toxicon. 2009 Jul;54(1):23-32.
7	Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53.
8	Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an alpha-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution. J Biomol NMR. 1997 Feb;9(2):127-35.
9	Cytotoxicity of pilosulin 1, a peptide from the venom of the jumper ant Myrmecia pilosula. Biochim Biophys Acta. 1998 Sep 16;1425(1):74-80.
10	Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. Arch Biochem Biophys. 2005 Feb 15;434(2):358-64.
11	Combined effects of curcumin and (-)-epigallocatechin gallate on inhibition of N-acylhomoserine lactone-mediated biofilm formation in wastewater bacteria from membrane bioreactor. J Microbiol Biotechnol. 2015 Nov;25(11):1908-19.

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