Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO04640)
Xenobiotics Name
Pleurocidin
Xenobiotics Type
Amino Acid(s), Peptide(s) or Protein(s)
Classification
Peptide
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Azoreductase (azoR) DME Info Enterococcus faecium [1]
Beta-lactamase (blaB) DME Info Serratia marcescens [2]
Azoreductase (azoR) DME Info Escherichia coli [2]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [2]
Beta-glucosidase (bglA) DME Info Enterococcus faecium [1]
Beta-lactamase (blaB) DME Info Escherichia coli [2]
Beta-lactamase (blaB) DME Info Salmonella enterica [2]
Beta-lactamase (blaB) DME Info Corynebacterium acnes [1]
Chloramphenicolase (chlR) DME Info Escherichia coli [2]
Glycoside hydrolase (cscA) DME Info Escherichia coli [2]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [2]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [2]
Unclear metabolic mechanism (DME-unclear) DME Info Salmonella enterica [2]
Unclear metabolic mechanism (DME-unclear) DME Info Streptococcus mutans [3]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [2]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [2]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [2]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [2]
Glutamate racemase (MurI) DME Info Escherichia coli [2]
Glutamate racemase (MurI) DME Info Streptococcus mutans [3]
Arylamine N-acetyltransferase (NAT) DME Info Serratia marcescens [2]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [2]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [2]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [2]
NADPH-dependent nitroreductase (nfrA1) DME Info Bacillus subtilis [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Salmonella enterica [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Salmonella enterica [2]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [2]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [2]
Glutamate racemase (MurI) DME Info Bacillus subtilis [2]
Tyramine oxidase (tynA) DME Info Escherichia coli [2]
Beta-glucuronidase (uidA) DME Info Escherichia coli [2]
VanA ligase (vanA) DME Info Enterococcus faecium [1]
VanB ligase (vanB) DME Info Enterococcus faecium [1]
Glutamate racemase (MurI) DME Info Bacillus pumilus [2]
General stress protein 14 (ywrO) DME Info Bacillus subtilis [2]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Beta-lactamase (blaB) DME Info MIC > 35.0 microM [2]
Azoreductase (azoR) DME Info MIC = 2.2-3.3 microM [2]
L,D-carboxypeptidase A (ldcA) DME Info MIC = 2.2-3.3 microM [2]
Beta-lactamase (blaB) DME Info MIC = 2.2-3.3 microM [2]
Beta-lactamase (blaB) DME Info MIC = 8.8-17.7 microM [2]
Chloramphenicolase (chlR) DME Info MIC = 2.2-3.3 microM [2]
Glycoside hydrolase (cscA) DME Info MIC = 2.2-3.3 microM [2]
NADPH-dependent curcumin reductase (curA) DME Info MIC = 2.2-3.3 microM [2]
Unclear metabolic mechanism (DME-unclear) DME Info MIC = 2.2-3.3 microM [2]
Unclear metabolic mechanism (DME-unclear) DME Info MIC = 8.8-17.7 microM [2]
Glutamate decarboxylase (gadB) DME Info MIC = 2.2-3.3 microM [2]
D-Lactate dehydrogenase (ldhA) DME Info MIC = 2.2-3.3 microM [2]
D-Lactate dehydrogenase (ldhA) DME Info MIC > 35.0 microM [2]
Molybdopterin-dependent enzyme (molD) DME Info MIC = 2.2-3.3 microM [2]
Glutamate racemase (MurI) DME Info MIC = 2.2-3.3 microM [2]
Arylamine N-acetyltransferase (NAT) DME Info MIC > 35.0 microM [2]
Arylamine N-acetyltransferase (NAT) DME Info MIC > 35.0 microM [2]
N-ethylmaleimide reductase (nemA) DME Info MIC = 2.2-3.3 microM [2]
NADPH-dependent oxidoreductase (nfrA) DME Info MIC = 17.7-35.0 microM [2]
NADPH-dependent nitroreductase (nfrA1) DME Info MIC = 1.1-2.2 microM [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info MIC = 2.2-3.3 microM [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info MIC = 8.8-17.7 microM [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info MIC = 2.2-3.3 microM [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info MIC = 8.8-17.7 microM [2]
NADH dehydrogenase (nuoE) DME Info MIC = 2.2-3.3 microM [2]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info MIC > 35.0 microM [2]
Glutamate racemase (MurI) DME Info MIC = 1.1-2.2 microM [2]
Tyramine oxidase (tynA) DME Info MIC = 2.2-3.3 microM [2]
Beta-glucuronidase (uidA) DME Info MIC = 2.2-3.3 microM [2]
Glutamate racemase (MurI) DME Info MIC = 1.1-2.2 microM [2]
General stress protein 14 (ywrO) DME Info MIC = 1.1-2.2 microM [2]
References
1 Antimicrobial peptide pleurocidin synergizes with antibiotics through hydroxyl radical formation and membrane damage, and exerts antibiofilm activity. Biochim Biophys Acta. 2012 Dec;1820(12):1831-8.
2 Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder. J Biol Chem. 1997 May 2;272(18):12008-13.
3 Antimicrobial and antibiofilm activity of pleurocidin against cariogenic microorganisms. Peptides. 2011 Aug;32(8):1748-54.

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