Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1298)
DME Name Beta-lactamase (blaB), Shigella sonnei DME Info
UniProt ID
Q2F4C6_SHISO
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Shigella sonnei     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Shigella
Species: Shigella sonnei
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      17 Xenobiotics
                              Antimicrobial peptide XT-6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02275   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide XT-6 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei (MIC = 35 microM) [1]
                              Bass hepcidin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02416   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bass hepcidin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei (MIC = 44 microM) [2], [3]
                              Cyclic cationic V1 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03029   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V1 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei (MIC = 0.005 microM) [4]
                              Cyclic cationic V2 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03030   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V2 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei (MIC = 0.005 microM) [4]
                              Cyclic cationic V3 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03031   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V3 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei (MIC = 0.005 microM) [4]
                              Cyclic cationic V4 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03032   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V4 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei (MIC = 0.01 microM) [4]
                              Cyclic cationic V5 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03033   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V5 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei (MIC = 0.692 microM) [4]
                              Cyclic cationic V6 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03034   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V6 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei (MIC = 0.004 microM) [4]
                              Cyclic cationic V7 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03035   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V7 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei (MIC = 0.007 microM) [4]
                              Enterocin AS-48 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03251   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin AS-48 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei [5]
                              Hagfish HFIAP-1/2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03556   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hagfish HFIAP-1/2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei (MIC = 2-4 ug/ml) [6]
                              Hagfish HFIAP-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03557   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hagfish HFIAP-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei (MIC = 2-4 ug/ml) [6]
                              Hematopoietic antimicrobial MgCath37 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03540   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hematopoietic antimicrobial MgCath37 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei (MIC = 2-4 ug/ml) [6]
                              Insect diptericin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03193   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Insect diptericin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei (MIC = 12.5 ug/ml) [7]
                              Microcin L Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04114   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Microcin L inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei [8], [9]
                              Sapecin defensin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04904   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Sapecin defensin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei (MIC > 78 ug/ml) [10], [11]
                              Sarcotoxin-1D Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04909   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Sarcotoxin-1D inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Shigella sonnei [10]
References
1 Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae). Biochim Biophys Acta. 2001 Nov 26;1550(1):81-9.
2 Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge. Eur J Biochem. 2002 Apr;269(8):2232-7.
3 Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections. J Biol Chem. 2005 Mar 11;280(10):9272-82.
4 De novo design of potent antimicrobial peptides. Antimicrob Agents Chemother. 2004 Sep;48(9):3349-57.
5 Bactericidal and bacteriolytic action of peptide antibiotic AS-48 against gram-positive and gram-negative bacteria and other organisms. Res Microbiol. 1989 Jan;140(1):57-68.
6 Hagfish intestinal antimicrobial peptides are ancient cathelicidins. Peptides. 2003 Nov;24(11):1655-67.
7 Purification and characterization of a diptericin homologue from Sarcophaga peregrina (flesh fly). Biochem J. 1992 Oct 15;287 ( Pt 2):573-8.
8 Genetic analysis and complete primary structure of microcin L. Antimicrob Agents Chemother. 2004 Feb;48(2):505-13.
9 Wild-type Escherichia coli producing microcins B17, D93, J25, and L; cloning of genes for microcin L production and immunity. Can J Microbiol. 2003 May;49(5):357-61.
10 Purification of three antibacterial proteins from the culture medium of NIH-Sape-4, an embryonic cell line of Sarcophaga peregrina. J Biol Chem. 1988 Nov 15;263(32):17112-6.
11 Determination of the disulfide array in sapecin, an antibacterial peptide of Sarcophaga peregrina (flesh fly). J Biochem. 1990 Apr;107(4):514-8.

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