Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1396)
DME Name Unclear metabolic mechanism (DME-unclear), Citrobacter freundii DME Info
Lineage    Species: Citrobacter freundii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Citrobacter
Species: Citrobacter freundii
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        8 Xenobiotics
                              Armadillidin glyc-rich Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02319   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Armadillidin glyc-rich inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Citrobacter freundii [1]
                              Bacteriocin L-1077 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02378   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin L-1077 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Citrobacter freundii (MIC = 0.76 ug/ml) [2]
                              Enterocin E-760 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03253   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin E-760 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Citrobacter freundii (MIC = 1.6 ug/ml) [3]
                              Hydramacin Hm-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03609   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hydramacin Hm-1 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Citrobacter freundii [4], [5]
                              Leptoglycin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03853   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Leptoglycin inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Citrobacter freundii (MIC = 75 microM) [6]
                              Magainin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03985   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Magainin-2 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Citrobacter freundii (MIC = 30 ug/ml) [7], [8]
                              Pilosulin Myr b I Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04606   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pilosulin Myr b I inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Citrobacter freundii (MIC = 2 microM) [9]
                              Pilosulin P1(1-20) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04426   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pilosulin P1(1-20) inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Citrobacter freundii (MIC = 2 microM) [10]
      Pharmaceutical Agent(s)
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Curcumin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00683   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Curcumin inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Citrobacter freundii [11]
                              Epigallocatechin gallate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00613   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Epigallocatechin gallate inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Citrobacter freundii [11]
References
1 Armadillidin: a novel glycine-rich antibacterial peptide directed against gram-positive bacteria in the woodlouse Armadillidium vulgare (Terrestrial Isopod, Crustacean). Dev Comp Immunol. 2005;29(6):489-99.
2 Isolation of Lactobacillus salivarius 1077 (NRRL B-50053) and characterization of its bacteriocin, including the antimicrobial activity spectrum. Appl Environ Microbiol. 2011 Apr;77(8):2749-54.
3 Isolation and purification of enterocin E-760 with broad antimicrobial activity against gram-positive and gram-negative bacteria. Antimicrob Agents Chemother. 2008 Mar;52(3):1094-100.
4 Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence. Dev Comp Immunol. 2009 Apr;33(4):559-69.
5 Hydramacin-1, structure and antibacterial activity of a protein from the basal metazoan Hydra. J Biol Chem. 2009 Jan 16;284(3):1896-905.
6 Leptoglycin: a new Glycine/Leucine-rich antimicrobial peptide isolated from the skin secretion of the South American frog Leptodactylus pentadactylus (Leptodactylidae). Toxicon. 2009 Jul;54(1):23-32.
7 Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53.
8 Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an alpha-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution. J Biomol NMR. 1997 Feb;9(2):127-35.
9 Cytotoxicity of pilosulin 1, a peptide from the venom of the jumper ant Myrmecia pilosula. Biochim Biophys Acta. 1998 Sep 16;1425(1):74-80.
10 Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. Arch Biochem Biophys. 2005 Feb 15;434(2):358-64.
11 Combined effects of curcumin and (-)-epigallocatechin gallate on inhibition of N-acylhomoserine lactone-mediated biofilm formation in wastewater bacteria from membrane bioreactor. J Microbiol Biotechnol. 2015 Nov;25(11):1908-19.

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