Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME0283)
DME Name Dimethylaniline oxidase 2 (FMO2), Homo sapiens
Synonyms Dimethylaniline monooxygenase [N-oxide-forming] 2; FMO 1B1; FMO 2; Pulmonary flavin-containing monooxygenase 2
Gene Name FMO2
UniProt ID
FMO2_HUMAN
Gene ID
2327
EC Number    EC: 1.14.13.8     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
NADH/NADPH donor oxidoreductase
EC: 1.14.13.8
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
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       Interactions between Microbiome and DME (MICBIO)                       
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MAKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGVWRFKENVEDGRASIYQSVVT
NTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVLSVRKCPDFS
SSGQWKVVTQSNGKEQSAVFDAVMVCSGHHILPHIPLKSFPGMERFKGQYFHSRQYKHPD
GFEGKRILVIGMGNSGSDIAVELSKNAAQVFISTRHGTWVMSRISEDGYPWDSVFHTRFR
SMLRNVLPRTAVKWMIEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCGAIKVK
STVKELTETSAIFEDGTVEENIDVIIFATGYSFSFPFLEDSLVKVENNMVSLYKYIFPAH
LDKSTLACIGLIQPLGSIFPTAELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLF
GESQSQTLQTNYVDYLDELALEIGAKPDFCSLLFKDPKLAVRLYFGPCNSYQYRLVGPGQ
WEGARNAIFTQKQRILKPLKTRALKDSSNFSVSFLLKILGLLAVVVAFFCQLQWS
Pathway Drug metabolism - cytochrome P450 (hsa00982 )
Function This enzyme catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. And it can catalyze the S-oxidation of methimazole.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          5 Drugs
Propranolol hydrochloride
 Drug Info Approved Migraine ICD11: 8A80 [1]
Methimazole
 Drug Info Approved Thyrotoxicosis ICD11: 5A02 [2]
Olopatadine
 Drug Info Approved Conjunctivitis ICD11: 9A60 [3]
Ethionamide
 Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [2]
Trifluoperazine
 Drug Info Approved Schizophrenia ICD11: 6A20 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR000970 Ethionamide Ethionamide sulphoxide Reduction - Reduction Ethionamide [4], [5]
References
1 Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis. Microb Cell Fact. 2015 Jun 12;14:82.
2 Drug metabolism by flavin-containing monooxygenases of human and mouse. Expert Opin Drug Metab Toxicol. 2017 Feb;13(2):167-181.
3 Effects of olopatadine, a new antiallergic agent, on human liver microsomal cytochrome P450 activities Drug Metab Dispos. 2002 Dec;30(12):1504-11. doi: 10.1124/dmd.30.12.1504.
4 Metabolism and pharmacokinetics of the anti-tuberculosis drug ethionamide in a flavin-containing monooxygenase null mouse Pharmaceuticals (Basel). 2012;5(11):1147-59. doi: 10.3390/ph5111147.
5 The metabolism of ethionamide and its sulphoxide J Pharm Pharmacol. 1967 Jan;19(1):1-9. doi: 10.1111/j.2042-7158.1967.tb07986.x.

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