Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1004)
DME Name Beta-lactamase (blaB), Enterobacter cloacae
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; blaFRI-4
Gene Name blaFRI-4
UniProt ID
A0A1S7IV31_ENTAS
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Enterobacter cloacae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Enterobacter
Species: Enterobacter cloacae
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MFFFKKSASTFIFLLCLPLNSFASQESNGVEQMRELETSFGGRIGVYILNTKNGKEFSYR
QDERFPLCSSFKAFLAASVLKRTQDKSVSLDDMMEYSGRVMEKHSPVSEKYRETGASVQT
LAKAAIQYSDNGASNLLMERYIGGPEGLTAFMRSTGDTDFRLDRWELELNSAIPGDERDT
STPKAVAISLNNIAFGSVLDAKNKSLLQDWLKGNTTGNARIRAAVPDKWVVGDKTGTCGL
YGTANDIAILWPDANSPAVMAVYTTRPNQNDKHDETVIKNAAKIAINAVYGSTK
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          3 Drugs
Doripenem
 Drug Info Approved Infectious cystitis ICD11: GC00 [1]
Ertapenem
 Drug Info Approved Pneumocystis pneumonia ICD11: CA40 [1]
Meropenem
 Drug Info Approved Pseudomonas infection ICD11: 1G40 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Imipenem
 Drug Info Phase 4 Acute pancreatitis ICD11: DC31 [1], [2]
References
1 FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan. J Antimicrob Chemother. 2018 Nov 1;73(11):2969-2972.
2 Survey of clinical extended-spectrum beta-lactamase-producing Enterobacter cloacae isolates in a Chinese Tertiary Hospital, 2012-2014. Microb Drug Resist. 2017 Jan;23(1):83-89.

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