Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1024)
DME Name Beta-lactamase (blaB), Klebsiella variicola
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; Beta-lactamase SHV-2; SHV-2A; bla; shv2
Gene Name bla
UniProt ID
BLA2_KLEPO
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Klebsiella variicola     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella variicola
Subspecies: Klebsiella variicola subsp. Ozaenae
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human lung.
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADE
RFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCA
AAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPA
SMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARG
IVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR
Function This enzyme hydrolyzes cefotaxime, ceftazidime and other broad spectrum cephalosporins.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          4 Drugs
Cefotaxime
 Drug Info Approved Meningitis ICD11: 1A62 [1], [2]
Aztreonam
 Drug Info Approved Cystic fibrosis ICD11: CA25 [1]
Cefoxitin
 Drug Info Approved Peritonitis ICD11: DC50 [1], [2]
Ceftriaxone
 Drug Info Approved Methicillin-resistant staphylococcus infection ICD11: 1D01 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Cefpirome
 Drug Info Phase 4 Pseudomonas infection ICD11: 1G40 [2]
References
1 Antibiotic resistance and production of extended-spectrum beta-lactamases amongst Klebsiella spp. from intensive care units in Europe. J Antimicrob Chemother. 1996 Sep;38(3):409-24.
2 Oral streptococcal strains isolated from odontogenic infections and their susceptibility to antibiotics. Rev Med Chir Soc Med Nat Iasi. 2006 Oct-Dec;110(4):1012-5.

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