General Information of Drug-Metabolizing Enzyme (DME ID: DME1024)
DME Name Beta-lactamase (blaB), Klebsiella variicola DME Info
UniProt ID
BLA2_KLEPO
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Klebsiella variicola     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella variicola
Subspecies: Klebsiella variicola subsp. Ozaenae
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:    162 Xenobiotics
                              Anopheles cecropin-A amidated isoform Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02230   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Anopheles cecropin-A amidated isoform inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 1-2.5 microM) [1], [2]
                              Antimicrobial peptide eNAP-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02280   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide eNAP-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [3]
                              Arachnid gomesin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03497   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Arachnid gomesin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 3.15-6.25 microM) [4]
                              Ascaphin-5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02325   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ascaphin-5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 13 microM) [5]
                              Bactenecin 5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02370   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bactenecin 5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [6]
                              Bactenecin 7 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02371   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bactenecin 7 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 12 ug/ml) [7]
                              Bacteriocin delta-lysin I Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03137   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin delta-lysin I inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [8]
                              Bacteriocin L-1077 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02378   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin L-1077 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 0.76 ug/ml) [9]
                              Bass hepcidin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02416   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bass hepcidin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [10], [11]
                              Big defensin crabs Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02451   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Big defensin crabs inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [12], [13]
                              Bradykinin-potentiating BmK3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02491   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bradykinin-potentiating BmK3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 2.8 microM) [14], [15]
                              Brevinin-1AUa Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02496   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Brevinin-1AUa inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 50 microM) [16]
                              Brevinin-1AUb Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02497   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Brevinin-1AUb inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC > 50 microM) [16]
                              Brevinin-1CG5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02512   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Brevinin-1CG5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 150 microM) [17]
                              Brevinin-1TSa Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02566   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Brevinin-1TSa inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC > 100 microM) [18]
                              Brevinin-2TSa Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02637   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Brevinin-2TSa inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 6 microM) [18]
                              Caerin-1.11 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02688   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Caerin-1.11 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 25 microM) [19], [20]
                              Caerulein precursor fragment-SP1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02942   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Caerulein precursor fragment-SP1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [21]
                              Canine beta-defensin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02708   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Canine beta-defensin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 20 ug/ml) [22]
                              Canine beta-defensin cBD-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02749   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Canine beta-defensin cBD-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 20 mug/ml) [22]
                              Cathelicidin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02732   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cathelicidin-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 1.25 microM) [23]
                              Cathelicidin-BF Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02743   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cathelicidin-BF inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 4.7 ug/ml) [24], [25]
                              Cecropin-B(1-7)-melittin(4-11) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02767   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-B(1-7)-melittin(4-11) hybrid inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [26]
                              CP-P derivative K11 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03678   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CP-P derivative K11 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 2 ug/ml) [27]
                              CTX-1 peptide NCP-3a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04241   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CTX-1 peptide NCP-3a inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [28]
                              CTX-1 peptide NCP-3b Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04242   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CTX-1 peptide NCP-3b inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [28]
                              Cyclic cationic V1 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03029   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V1 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 0.145 microM) [29]
                              Cyclic cationic V2 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03030   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V2 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 0.643 microM) [29]
                              Cyclic cationic V3 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03031   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V3 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 0.01 microM) [29]
                              Cyclic cationic V4 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03032   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V4 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC < 0.005 microM) [29]
                              Cyclic cationic V5 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03033   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V5 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC > 0.692 microM) [29]
                              Cyclic cationic V6 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03034   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V6 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 0.004 microM) [29]
                              Cyclic cationic V7 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03035   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V7 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 0.458 microM) [29]
                              Decoralin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03089   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Decoralin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 80 microM) [30]
                              Defensin Cll-dlp Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03112   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Defensin Cll-dlp inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC > 50 ug/ml) [31]
                              Defensin sapecin-B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04905   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Defensin sapecin-B inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [32], [33]
                              Dermaseptin-like PBN2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03162   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Dermaseptin-like PBN2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 0.8 microM) [19]
                              Drosophila cecropin-A1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03224   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Drosophila cecropin-A1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 1-2.5 microM) [34], [35]
                              Dybowskin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03235   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Dybowskin-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 60 ug/ml) [36]
                              Dybowskin-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03237   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Dybowskin-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC > 100 ug/ml) [36]
                              Dybowskin-4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03238   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Dybowskin-4 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 15 ug/ml) [36]
                              Dybowskin-5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03239   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Dybowskin-5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 50 ug/ml) [36]
                              Enterocin 96 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03250   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin 96 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [37]
                              Enterocin AS-48 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03251   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin AS-48 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [38]
                              Enterocin E-760 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03253   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin E-760 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 3.2 ug/ml) [39]
                              Fowlicidin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02734   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Fowlicidin-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 0.40 microM) [40]
                              Fowlicidin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02736   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Fowlicidin-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 0.66 microM) [41]
                              Fowlicidin-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02738   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Fowlicidin-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 1 microM) [42]
                              Gaegurin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03436   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gaegurin-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 100 ug/ml) [43]
                              Gaegurin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03437   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gaegurin-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 25 ug/ml) [43]
                              Gaegurin-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03438   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gaegurin-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 25 ug/ml) [43]
                              Gaegurin-4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03439   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gaegurin-4 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 25 ug/ml) [44]
                              Gaegurin-5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03440   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gaegurin-5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 50 ug/ml) [43]
                              Gaegurin-6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03441   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gaegurin-6 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 50 ug/ml) [43]
                              GGN4 analogue peptide D16W Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03052   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation GGN4 analogue peptide D16W inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 10 ug/ml) [45]
                              Gly-rich Pg-AMP Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04548   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gly-rich Pg-AMP inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 32000 ug/ml) [46]
                              Hadrurin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03519   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hadrurin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [47]
                              Hagfish HFIAP-1/2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03556   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hagfish HFIAP-1/2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 8-16 ug/ml) [48]
                              Hagfish HFIAP-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03557   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hagfish HFIAP-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 8-16 ug/ml) [48]
                              Halocyntin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03522   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Halocyntin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [49]
                              Heligoland antimicrobial peptide A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04762   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Heligoland antimicrobial peptide A inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC > 25 microM) [50]
                              Hematopoietic antimicrobial MgCath37 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03540   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hematopoietic antimicrobial MgCath37 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 8-16 ug/ml) [48]
                              Heteroscorpine-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03549   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Heteroscorpine-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [51]
                              Human beta-defensin hBD-28 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03591   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Human beta-defensin hBD-28 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 50 ug/ml) [52]
                              Human beta-defensin hBD-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03593   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Human beta-defensin hBD-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 25 ug/ml) [52], [53]
                              Hydramacin Hm-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03609   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hydramacin Hm-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [54], [55]
                              Immobilized peptide E07LKK Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03633   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Immobilized peptide E07LKK inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [56]
                              Immobilized peptide E10KKL Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03630   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Immobilized peptide E10KKL inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [56]
                              Immobilized peptide E12LLK Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03631   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Immobilized peptide E12LLK inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [56]
                              Immobilized peptide E14KKL Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03632   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Immobilized peptide E14KKL inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [56]
                              Immobilized peptide E14LKK/H14LKK Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03634   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Immobilized peptide E14LKK/H14LKK inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [56]
                              Immobilized peptide E16LKL Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03635   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Immobilized peptide E16LKL inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [56]
                              Immobilized peptide E17HSA magainin 2 deletion Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03636   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Immobilized peptide E17HSA magainin 2 deletion inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [56]
                              Immobilized peptide E17KGG Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03637   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Immobilized peptide E17KGG inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [56]
                              Immobilized peptide E18KGG Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03638   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Immobilized peptide E18KGG inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [56]
                              Immobilized peptide E23GIG magainin 2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03639   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Immobilized peptide E23GIG magainin 2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [56]
                              Immobilized peptige E16KGL/H16KGL Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03640   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Immobilized peptige E16KGL/H16KGL inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [56]
                              Insect cecropin-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02768   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Insect cecropin-A inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 1-2.5 ug/ml) [57]
                              Jellein-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03672   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Jellein-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 10 ug/ml) [58]
                              Jellein-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03673   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Jellein-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 15 ug/ml) [58]
                              Jellein-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03674   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Jellein-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [58]
                              Jindongenin-1a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03675   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Jindongenin-1a inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 15 microM) [59]
                              Kassinatuerin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03697   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Kassinatuerin-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 25 microM) [60], [61]
                              L10 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03724   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L10 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 3.35 microM) [62]
                              L5K5Wn model peptide L5K5W1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03746   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 2 ug/ml) [63]
                              L5K5Wn model peptide L5K5W10 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03747   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W10 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 2 ug/ml) [63]
                              L5K5Wn model peptide L5K5W11 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03748   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W11 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 4 ug/ml) [63]
                              L5K5Wn model peptide L5K5W2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03749   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 2 ug/ml) [63]
                              L5K5Wn model peptide L5K5W3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03750   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 2 ug/ml) [63]
                              L5K5Wn model peptide L5K5W4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03751   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W4 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 4 ug/ml) [63]
                              L5K5Wn model peptide L5K5W5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03752   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 2 ug/ml) [63]
                              L5K5Wn model peptide L5K5W7 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03754   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W7 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 2 ug/ml) [63]
                              L5K5Wn model peptide L5K5W8 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03755   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W8 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 4 ug/ml) [63]
                              L5K5Wn model peptide L5K5W9 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03756   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W9 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 2 ug/ml) [63]
                              LlKmWn model peptide L5K3W5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03744   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation LlKmWn model peptide L5K3W5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 6.3 ug/ml) [64]
                              LlKmWn model peptide L5K5W6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03753   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation LlKmWn model peptide L5K5W6 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 6.3 ug/ml) [64]
                              LlKmWn model peptide L6K4W6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03759   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation LlKmWn model peptide L6K4W6 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 3.1 ug/ml) [64]
                              LlKmWn model peptide L7K3W6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03761   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation LlKmWn model peptide L7K3W6 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 50 ug/ml) [64]
                              Magainin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03985   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Magainin-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 10 ug/ml) [65], [66]
                              Mastoparan MP-L Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04001   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mastoparan MP-L inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 12.5 microM) [67]
                              Mastoparan-L [I5,R8] derivative Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01816   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mastoparan-L [I5,R8] derivative inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 6.25 microM) [67]
                              Maximin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04007   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Maximin-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 9 ug/ml) [68], [69]
                              Maximin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04011   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Maximin-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 9 ug/ml) [68], [69]
                              Maximin-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04012   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Maximin-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 3.1 ug/ml) [68], [69]
                              Maximin-4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04013   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Maximin-4 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 15 ug/ml) [68], [69]
                              Maximin-5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04014   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Maximin-5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 3.6 ug/ml) [68], [69]
                              Microcin 7 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04111   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Microcin 7 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [70]
                              Mollusca/molluscs/mollusks peptide 2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04531   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mollusca/molluscs/mollusks peptide 2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [71]
                              Mollusca/molluscs/mollusks peptide 3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04533   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mollusca/molluscs/mollusks peptide 3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [71]
                              Mollusca/molluscs/mollusks peptide 4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04534   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mollusca/molluscs/mollusks peptide 4 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [71]
                              Mollusca/molluscs/mollusks peptide 5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04535   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mollusca/molluscs/mollusks peptide 5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [71]
                              Mollusca/molluscs/mollusks peptide 6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04536   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mollusca/molluscs/mollusks peptide 6 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [71]
                              Mollusca/molluscs/mollusks peptide 7 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04537   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mollusca/molluscs/mollusks peptide 7 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [71]
                              Mollusca/molluscs/mollusks peptide 8 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04538   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mollusca/molluscs/mollusks peptide 8 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [71]
                              Mollusca/molluscs/mollusks peptide 9 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04539   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mollusca/molluscs/mollusks peptide 9 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [71]
                              Nematode ABF-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02115   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Nematode ABF-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [72]
                              Ocellatin-F1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04348   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ocellatin-F1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 80 microM) [73]
                              Ocellatin-P1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04349   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ocellatin-P1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 100 microM) [74]
                              Opistoporin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04399   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Opistoporin-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 6.3 microM) [75]
                              Papillosin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04468   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Papillosin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [49]
                              Parabutoporin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04471   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Parabutoporin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 1.6 microM) [76]
                              Penaeidin-2d Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04506   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penaeidin-2d inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC > 20 microM) [77], [78]
                              Penaeidin-3a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04507   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penaeidin-3a inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC > 40 microM) [79]
                              Penaeidin-3a T8A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01827   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penaeidin-3a T8A inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC > 50 microM) [79]
                              Penaeidin-4a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04510   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penaeidin-4a inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC > 50 microM) [77], [80]
                              Phylloseptin PS-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04571   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Phylloseptin PS-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [81]
                              Phylloseptin PS-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04572   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Phylloseptin PS-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [82], [83]
                              Pilosulin Myr b I Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04606   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pilosulin Myr b I inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 2 microM) [84]
                              Pilosulin P1(1-20) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04426   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pilosulin P1(1-20) inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 2 microM) [85]
                              Piscidin Pis-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04612   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Piscidin Pis-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 2.5-5 microM) [86]
                              Piscidin Pis-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04613   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Piscidin Pis-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 2.5-5 microM) [87]
                              Ponericin G1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04695   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [88]
                              Ponericin G3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04696   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [88]
                              Ponericin G4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04697   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G4 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [88]
                              Ponericin G6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04698   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G6 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [88]
                              Ponericin-L2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04699   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-L2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [88]
                              Ponericin-W1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04700   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [88]
                              Ponericin-W3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04701   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [88]
                              Ponericin-W4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04702   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W4 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [88]
                              Ponericin-W5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04703   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [88]
                              PYLa/PGLa A chain PGLa Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04549   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation PYLa/PGLa A chain PGLa inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 250-500 ug/ml) [89], [90]
                              Ranatuerin-2AUa Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04809   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ranatuerin-2AUa inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 10 microM) [16]
                              SAAP fraction 3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04891   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation SAAP fraction 3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [91]
                              Sapecin-C Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04906   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Sapecin-C inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [32]
                              Scorpine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04917   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Scorpine inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 10 microM) [92]
                              Single AA substitution D16F-N23 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03051   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Single AA substitution D16F-N23 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 100 ug/ml) [45]
                              Single AA substitution D16W-N23 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03053   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Single AA substitution D16W-N23 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 25 ug/ml) [45]
                              Spheniscin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04971   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Spheniscin-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 50-100 microM) [93], [94]
                              Spider gomesin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03498   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Spider gomesin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 3.15-6.25 microM) [4]
                              Spinigerin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04974   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Spinigerin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 50-100 microM) [95], [96]
                              Stomoxyn Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04995   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Stomoxyn inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 0.78-1.56 microM) [96], [97]
                              Tachycitin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05020   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Tachycitin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [98], [99]
                              Temporin-1Va Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05073   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-1Va inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 80 microM) [100]
                              Temporin-1Vc Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05075   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-1Vc inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 80 microM) [100]
                              Temporin-Ra Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05101   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-Ra inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 31.2 ug/ml) [101]
                              Temporin-Rb Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05102   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-Rb inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 35.1 ug/ml) [101]
                              Thanatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05120   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thanatin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 0.6-1.2 microM) [102], [103]
                              Thanatin truncated isoform I14M(8-21) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03622   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thanatin truncated isoform I14M(8-21) inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 20-40 microM) [102]
                              Thanatin truncated isoform K18M(4-21) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03681   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thanatin truncated isoform K18M(4-21) inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 1.2-2.5 microM) [102]
                              Thanatin truncated isoform V16M(6-21) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05220   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thanatin truncated isoform V16M(6-21) inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 2.5-5 microM) [102]
                              Toad bombinin-like peptide BLP-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02473   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Toad bombinin-like peptide BLP-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [104], [105]
                              Tracheal antimicrobial peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05163   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Tracheal antimicrobial peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola (MIC = 12-25 ug/ml) [106], [107]
      Natural Product(s), Extract(s) or Medicine(s)
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Himatanthus drasticus butanolic extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02656   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Himatanthus drasticus butanolic extract inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [108]
                              Himatanthus drasticus hydroalcoholic extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03611   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Himatanthus drasticus hydroalcoholic extract inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [108]
                              Hyptis suaveolens hexane extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03552   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Hyptis suaveolens hexane extract inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [109]
                              Thymus vulgaris ethanol extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03348   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Thymus vulgaris ethanol extract inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [110]
                              Thymus vulgaris methanol extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04087   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Thymus vulgaris methanol extract inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [110]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cefixime Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02780   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cefixime inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [111]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Salicylic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00546   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation Salicylic acid inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [112]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Cyanidin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01266   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Cyanidin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [113]
                              Phenanthrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00574   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Phenanthrene inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [109]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Norspermidine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04331   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Norspermidine inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [114]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Ferric chloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03387   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Ferric chloride inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella variicola [115]
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111 Antibiofilm potential of 16-oxo-cleroda-3, 13(14) E-diene-15 oic acid and its five new gama-amino gama-lactone derivatives against methicillin resistant Staphylococcus aureus and Streptococcus mutans. Eur J Med Chem. 2017 Sep 29;138:480-490.
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115 Inhibiting biofilm formation by Klebsiella pneumoniae B5055 using an iron antagonizing molecule and a bacteriophage. BMC Microbiol. 2013 Jul 26;13:174.

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