Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1088)
DME Name Hydroxybenzoate 3-monooxygenase (pobA), Pseudomonas fluorescens
Synonyms Hydroxybenzoate hydroxylase; 4-hydroxybenzoate 3-monooxygenase; p-hydroxybenzoate hydroxylase; PHBH; pobA
Gene Name pobA
UniProt ID
PHHY_PSEFL
EC Number    EC: 1.14.13.2     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
NADH/NADPH donor oxidoreductase
EC: 1.14.13.2
Lineage    Species: Pseudomonas fluorescens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Pseudomonadaceae
Genus: Pseudomonas
Species: Pseudomonas fluorescens
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKTQVAIIGAGPSGLLLGQLLHKAGIDNVILERQTPDYVLGRIRAGVLEQGMVDLLREAG
VDRRMARDGLVHEGVEIAFAGQRRRIDLKRLSGGKTVTVYGQTEVTRDLMEAREACGATT
VYQAAEVRLHDLQGERPYVTFERDGERLRLDCDYIAGCDGFHGISRQSIPAERLKVFERV
YPFGWLGLLADTPPVSHELIYANHPRGFALCSQRSATRSRYYVQVPLTEKVEDWSDERFW
TELKARLPAEVAEKLVTGPSLEKSIAPLRSFVVEPMQHGRLFLAGDAAHIVPPTGAKGLN
LAASDVSTLYRLLLKAYREGRGELLERYSAICLRRIWKAERFSWWMTSVLHRFPDTDAFS
QRIQQTELEYYLGSEAGLATIAENYVGLPYEEIE
Structure
1BF3 ; 1BGJ ; 1BGN ; 1BKW ; 1CC4 ; 1CC6 ; 1CJ2 ; 1CJ3 ; 1CJ4 ; 1PBB ; 1PBC ; 1PBD ; 1PBE ; 1PBF ; 1PDH
Function This enzyme is a flavoprotein (FAD) and can catalyzes the incorporation of an atom of dioxygen into p-hydroxybenzoate (p-OHB) to form 3,4-dihydroxybenzoate (3,4DOHB).
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Tetracycline
 Drug Info Approved Spotted fever ICD11: 1C31 [1]
References
1 Structural comparison of p-hydroxybenzoate hydroxylase (PobA) from Pseudomonas putida with PobA from other Pseudomonas spp. and other monooxygenases. Acta Crystallogr F Struct Biol Commun. 2019 Jul 1;75(Pt 7):507-514.

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