Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1196)
DME Name Cytidine deaminase (cdd), Mycoplasma hyorhinis
Synonyms Cytidine aminohydrolase; Activation-induced cytidine deaminase; Canine hepatic cyd deaminase; AICDA; MHR_0312
Gene Name cdd
UniProt ID
E0TLJ6_MYCHH
EC Number    EC: 3.5.4.5     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amidine hydrolase
EC: 3.5.4.5
Lineage    Species: Mycoplasma hyorhinis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Tenericutes
Class: Mollicutes
Order: Mycoplasmatales
Family: Mycoplasmataceae
Genus: Mycoplasma
Species: Mycoplasma hyorhinis
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MFQELEKLLKITYSPYSKFPVAAVIKDAKGNIWKGVNVENAAYPSGLCAERNALFSSITY
GFIPGKIQEIHILANTKEFIKPCAACLQVMIELMEYDADVYLYSITGAVEKRKLVEFLPL
AFRKEFLN
Pathway Metabolic pathways (mhr01100 )
Pyrimidine metabolism (mhr00240 )
Function This enzyme catalyzes the deamination of cytidine and 2'-deoxycytidine with similar efficiencies. It is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          4 Drugs
Gemcitabine
 Drug Info Approved Breast cancer ICD11: 2C60 [1]
Azacitidine
 Drug Info Approved Myelodysplastic syndrome ICD11: 2A36 [1]
Cytarabine
 Drug Info Approved Acute lymphoblastic leukemia ICD11: 2B33 [1]
Decitabine
 Drug Info Approved Myelodysplastic syndrome ICD11: 2A36 [1]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          2 Drugs
Gemcitabine
 Drug Info Approved Breast cancer Km = 2586 microM [1]
Cytarabine
 Drug Info Approved Acute lymphoblastic leukemia Km = 6172 microM [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR002521 5'-DFCR 5'-DFUR Unclear - Unclear Capecitabine [2], [3]
References
1 Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9.
2 EUCRISA? (crisaborole) ointment, 2%, for topical use
3 A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma

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