Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1204)
DME Name Beta-glucosidase (bglA), Actinosynnema mirum
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; Amir_1683
Gene Name bglA
UniProt ID
C6WCL5_ACTMD
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Actinosynnema mirum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Pseudonocardiales
Family: Pseudonocardiaceae
Genus: Actinosynnema
Species: Actinosynnema mirum
Subspecies: Actinosynnema mirum KACC 20028
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MDTTARAAGFDPAIASLPPSFRWGVATSAYQIEGAVAEDGRGPSIWDTYCRVPGMVHEGD
NGDVACDHYHRMPEDVELIRSLGVDTYRFSVAWPRVQPGGTGPANPKGLAFYDRLVDELL
AKGVDPWVTLYHWDLPQELEDAGGWPVRDTAHRFADYSMLVFDALQDRVRTWTTLNEPWC
SAMLGYHVGRQAPGRTHFPDAIKAVHHLLLGHGLATRRMREAAVKPTEFGITLNMGHAAP
ATDSELDRDAARRADGLGRRIYLHPVVTGEYPADVVADLAARGAELPVRDGDLELISQPI
EVLGINHYTSSKHSGTAEDGSTVDADGLPVDRELRYGRPVTAMDWEIVPEQFTELLLQNA
REYPDLPPMVITENGAAFDDVVSPDGSVDDADRVAYLDSHIAAVAKAREGGADVRGYFAW
SLMDNFEWSYGYEKRFGIVHVDYETQVRTPKASALWYRDVAKRVRES
Pathway Biosynthesis of secondary metabolites (ami01110 )
Cyanoamino acid metabolism (ami00460 )
Metabolic pathways (ami01100 )
Starch and sucrose metabolism (ami00500 )
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
SC-46553
 Drug Info Phase 3 Cerebral stroke ICD11: 8B11 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          3 Drugs
Ginsenoside Re
 Drug Info Investigative Lung cancer ICD11: 2C25 [1]
Ginsenoside Rg1
 Drug Info Investigative Insomnia ICD11: 7A00 [1]
Ginsenoside Rb1
 Drug Info Investigative Obesity ICD11: 5B81 [1]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          2 Drugs
SC-46553
 Drug Info Phase 3 Cerebral stroke Km = 450 microM [1]
Ginsenoside Rb1
 Drug Info Investigative Obesity Km = 690 microM [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR001401 Lactulose Lactic acid Oxidation - N-Dealkylation Lactulose [2]
MR001402 Lactulose Formic acid Oxidation - N-Dealkylation Lactulose [2]
MR001403 Lactulose Acetic acid Oxidation - N-Dealkylation Lactulose [2]
References
1 Characterization of the ginsenoside-transforming recombinant beta-glucosidase from Actinosynnema mirum and bioconversion of major ginsenosides into minor ginsenosides. Appl Microbiol Biotechnol. 2013 Jan;97(2):649-59.
2 LABEL:ACTULOSE- lactulose solution

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