Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1231)
DME Name Beta-lactamase (blaB), Serratia marcescens
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; PAU_00771; PA-RVA13-1244
Gene Name ampC
UniProt ID
AMPC_SERMA
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Serratia marcescens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Yersiniaceae
Genus: Serratia
Species: Serratia marcescens
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTKMNRCAALIAALILPTAHAAQQQDIDAVIQPLMKKYGVPGMAIAVSVDGKQQIYPYGV
ASKQTGKPITEQTLFEVGSLSKTFTATLAVYAQQQSKLSFKDPASHYLPDVRGSAFDGVS
LLNLATHTSGLPLFVPDDVTNNAQLMAYYRAWQPKHPAGSYRVYSNLGIGMLGMIAAKSL
DQPFIQAMEQGMLPALGMSHTYVQVPAAQMANYAQGYSKDDKPVRVNPGPLDAESYGIKS
NARDLIRYLDANLQQVKVASVARRWPRRTSVITSAGAFTQDLMWENYPYPVKLSRLIEGN
NAGMIMNGTPATAITPPQPELRAGWYNKTGSTGGFSTYAVFIPAKNIAVEMLANKWFPND
DRVEAAYHIIQALEKR
Function This enzyme hydrolyzes beta-lactam with a substrate specificity for cephalosporins.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          4 Drugs
Cefotaxime
 Drug Info Approved Meningitis ICD11: 1A62 [1]
Piperacillin
 Drug Info Approved Pneumocystis pneumonia ICD11: CA40 [1]
Tazobactam
 Drug Info Approved Pseudomonas infection ICD11: 1G40 [1]
Ceftriaxone
 Drug Info Approved Methicillin-resistant staphylococcus infection ICD11: 1D01 [1], [2]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Imipenem
 Drug Info Phase 4 Acute pancreatitis ICD11: DC31 [3], [4]
References
1 Determination of the antibiotic resistance rates of Serratia marcescens isolates obtained from various clinical specimens. Niger J Clin Pract. 2019 Jan;22(1):125-130.
2 Serratia marcescens is injurious to intestinal epithelial cells. Gut Microbes. 2014;5(6):729-36.
3 Antibiotic therapy for inducible AmpC beta-lactamase-producing Gram-negative bacilli: what are the alternatives to carbapenems, quinolones and aminoglycosides? Int J Antimicrob Agents. 2012 Oct;40(4):297-305.
4 Serratia marcescens producing SME carbapenemases: an emerging resistance problem in the UK? J Antimicrob Chemother. 2017 May 1;72(5):1535-1537.

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