Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1243)
DME Name NADPH-dependent nitroreductase (nfrA1), Bacillus subtilis
Synonyms NADPH-dependent FMN reductase; NADPH-dependent nitro/flavin reductase; NADPH-dependent oxidoreductase; FMN reductase (NADPH); BSU38110; ipa-43d; nfrA1; ywcG
Gene Name nfrA1
UniProt ID
NFRA1_BACSU
Gene ID
937279
EC Number    EC: 1.5.1.38     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.38
Lineage    Species: Bacillus subtilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus subtilis
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQAYSIIGVSDPEKKREL
SVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLENTEMFMVSLIDAALAAQN
MSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFGLAVGHPANLSGKKPRLPKQA
VYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKREETWSDQILNFMKQKPRTYLNDY
VKEKGFNKN
Structure
3N2S
Pathway Metabolic pathways (bsu01100 )
Riboflavin metabolism (bsu00740 )
Function This enzyme can reduce FMNH(2) to FMN, with NADPH as reductant, and also can reduce nitroaromatic compounds, quinones and azo dyes.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Nitrofurantoin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1], [2]
Riboflavin
 Drug Info Approved Acne vulgaris ICD11: ED80 [1]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Nitrofural
 Drug Info Phase 3 Acute tonsillitis ICD11: CA03 [1], [2]
References
1 Conversion of NfsA, the major Escherichia coli nitroreductase, to a flavin reductase with an activity similar to that of Frp, a flavin reductase in Vibrio harveyi, by a single amino acid substitution. J Bacteriol. 1998 Jan;180(2):422-5.
2 Bacillus subtilis isolated from the human gastrointestinal tract. Res Microbiol. 2009 Mar;160(2):134-43.

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