Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1462)
DME Name Unclear metabolic mechanism (DME-unclear), Salmonella enterica
Gene Name DME-unclear
Lineage    Species: Salmonella enterica     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella enterica
Subspecies: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Subspecies: Salmonella enterica subsp. enterica serovar Typhimurium ST213
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        14 Drugs
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Fluoxetine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Danazol
 Drug Info Approved Endometriosis ICD11: GA10 [1]
Nalidixic acid
 Drug Info Approved Infectious cystitis ICD11: GC00 [2]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Ciprofloxacin
 Drug Info Approved Endocarditis ICD11: 1B12 [3]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Quinapril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Capecitabine
 Drug Info Approved Colon cancer ICD11: 2B90 [1]
Olmesartan medoxomil
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Cephalosporin
 Drug Info Approved Pneumocystis pneumonia ICD11: CA40 [4]
Cetirizine
 Drug Info Approved Allergy ICD11: 4A80 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          4 Drugs
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Trimebutine
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Nicergoline
 Drug Info Phase 4 Acne vulgaris ICD11: ED80 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
Roxatidine
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
2 Molecular level understanding of resistance to nalidixic acid in Salmonella enteric serovar typhimurium associates with the S83F sequence type. Eur Biophys J. 2016 Jan;45(1):35-44.
3 Eugenol derivatives prospectively inhibit l-asparaginase: a heady target protein of Salmonella typhimurium. Microb Pathog. 2018 Jan;114:8-16.
4 A multi-drug resistant Salmonella Typhimurium ST213 human-invasive strain (33676) containing the bla CMY-2 gene on an IncF plasmid is attenuated for virulence in BALB/c mice. BMC Microbiol. 2016 Feb 9;16:18.

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