Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1472)
DME Name Cytochrome P450 21A2 (cyp21), Bacillus megaterium
Synonyms Cytochrome P450 family 21 subfamily A member 2; Cytochrome cyp21A2; P450 21A2; cyp21A2
Gene Name cyp158a2_1
UniProt ID
A0A250VKS1_STROL
Gene ID
34823218
EC Number    EC: 1.14.14.16     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.16
Lineage    Species: Bacillus megaterium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus megaterium
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTEKTMPGPLPPVRHWPALDLKGVDFDPVLSELMREGPVTRIQLPNGEGWAWLVTRHDDV
RMVANDPRFGREAVVDQPVTRLAPHFIPARGAVGFLDPPDHTRLRRSVAAAFTARGVERV
RDKARRTLDVMVDELLRIGPPADLTEAVLSPFPIAVICELMGVPADDRRGMHTWTQLILS
SAHGAEVSEKAKDEMGAYFRKLIGARNDSRDEDVTSLLGAAVGRDEIDLEEAVGLAVLLQ
IGGEAVTNNSGQMFYLLLTRPALADRLRSDPRIRPQAIDELLRYIPHRNMVGLSRIARED
VEIRGVQIRAGDPIYVSYLAANRDPEVFPDPEHIDFGRSPNPHVAFGFGPHYCPGGMLAR
LESELLVEALVDRLPGLRLAVPPSQVPFRKGALIRGPEALPVTW
Function This enzyme is a P-450 heme-thiolate protein and it responsible for the conversion of progesterone and 17alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol. Involved in the biosynthesis of the hormones aldosterone and cortisol. The electron donor is NADPH---hemoprotein reductase.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Progesterone
 Drug Info Approved Premature labour ICD11: JB00 [1], [2]
References
1 acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.
2 A Novel NADPH-dependent flavoprotein reductase from Bacillus megaterium acts as an efficient cytochrome P450 reductase. J Biotechnol. 2016 Aug 10;231:83-94.

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