Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1472)
DME Name	Cytochrome P450 21A2 (cyp21), Bacillus megaterium	DME Info
UniProt ID	A0A250VKS1_STROL
EC Number	EC: 1.14.14.16 (Click to Show/Hide the Complete EC Tree) Oxidoreductase Oxygen paired donor oxidoreductase Flavin/flavoprotein donor oxidoreductase EC: 1.14.14.16
Lineage	Species: Bacillus megaterium (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Bacillales Family: Bacillaceae Genus: Bacillus Species: Bacillus megaterium
Interactome

Interactions between Xenobiotics and DME (XEOTIC)
Amino Acid(s), Peptide(s) or Protein(s)
Peptide		Click to Show/Hide the Full List of Xenobiotics: 159 Xenobiotics
Anopheles cecropin-A amidated isoform		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02230 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Anopheles cecropin-A amidated isoform inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.5-1 microM)				[1], [2]
Antibacterial napin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02237 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antibacterial napin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 215 microM)				[3]
Antibacterial peptide 3910		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02238 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antibacterial peptide 3910 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[4]
Antibacterial peptide PMAP-23		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02242 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antibacterial peptide PMAP-23 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2 microM)				[5]
Antibacterial peptide PMAP-36		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02243 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antibacterial peptide PMAP-36 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3 microM)				[6]
Antibacterial peptide PMAP-37		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02244 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antibacterial peptide PMAP-37 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 4 microM)				[7]
Antibacterial protein PR-39		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02248 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antibacterial protein PR-39 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.3 microM)				[8], [9]
Antimicrobial peptide AC-AMP1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02259 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antimicrobial peptide AC-AMP1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[10], [11]
Antimicrobial peptide AC-AMP2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02267 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antimicrobial peptide AC-AMP2 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[11]
Antimicrobial peptide GP-19		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02282 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antimicrobial peptide GP-19 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[12]
Antimicrobial peptide MJ-AMP1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02262 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antimicrobial peptide MJ-AMP1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 6 ug/ml)				[13], [14]
Antimicrobial peptide MJ-AMP2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02269 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antimicrobial peptide MJ-AMP2 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2 ug/ml)				[13], [14]
Antimicrobial peptide NK-lysin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02293 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antimicrobial peptide NK-lysin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.8 microM)				[15], [16]
Antimicrobial protein Ace-AMP1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02299 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antimicrobial protein Ace-AMP1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[17], [18]
Apidaecin-1A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02304 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Apidaecin-1A inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 150 ug/ml)				[19]
Apidaecin-1B		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02305 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Apidaecin-1B inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 100 ug/ml)				[19], [20]
Apidaecin-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02306 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Apidaecin-2 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 100 ug/ml)				[19]
Arachnid gomesin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03497 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Arachnid gomesin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.2-0.4 microM)				[21]
Armadillidin glyc-rich		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02319 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Armadillidin glyc-rich inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.5-1.25 microM)				[22]
Arthropods theromacin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05125 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Arthropods theromacin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[23]
Bacteriocin delta-lysin I		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03137 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bacteriocin delta-lysin I inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[24]
Bacteriocin HJ50		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02476 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bacteriocin HJ50 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[25], [26]
Bombin H7		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02468 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bombin H7 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3.3 microM)				[27]
Bombinin-like peptide BLP-3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02475 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bombinin-like peptide BLP-3 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.3 microM)				[28]
Bovine cathelicidin BMAP-34		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02466 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bovine cathelicidin BMAP-34 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3 microM)				[29], [30]
Brevinin-1E		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02521 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-1E inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.4 microM)				[31], [32]
Brevinin-2E		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02584 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-2E inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.2 microM)				[31]
Cathelicidin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02731 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cathelicidin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 4 microM)				[33], [34]
Cathelicidin-5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02739 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cathelicidin-5 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2 microM)				[35], [36]
Cathelicidin-6		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02740 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cathelicidin-6 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2 ug/ml)				[35], [37]
Cecropin-A(1-7)-melittin(1-8) hybrid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02756 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cecropin-A(1-7)-melittin(1-8) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.8 microM)				[38]
Cecropin-A(1-7)-melittin(2-9) hybrid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02757 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cecropin-A(1-7)-melittin(2-9) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.7 microM)				[38], [39]
Cecropin-A(1-7)-melittin(3-10) hybrid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02758 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cecropin-A(1-7)-melittin(3-10) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.9 microM)				[38]
Cecropin-A(1-7)-melittin(4-11) hybrid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02759 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cecropin-A(1-7)-melittin(4-11) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.5 microM)				[38], [40]
Cecropin-A(1-7)-melittin(5-12) hybrid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02760 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cecropin-A(1-7)-melittin(5-12) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.5 microM)				[38]
Cecropin-A(1-7)-melittin(6-13) hybrid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02761 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cecropin-A(1-7)-melittin(6-13) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.5 microM)				[38]
Cecropin-A(1-8)-Magainin-2(1-12) hybrid P18		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04430 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cecropin-A(1-8)-Magainin-2(1-12) hybrid P18 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.78 microM)				[41], [42]
Cecropin-A(1-8)-melittin(1-10) hybrid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02762 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cecropin-A(1-8)-melittin(1-10) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.5 microM)				[38]
Cecropin-A(1-8)-melittin(1-12) hybrid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02763 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cecropin-A(1-8)-melittin(1-12) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.2 microM)				[38]
Cecropin-A(1-8)-melittin(1-18) hybrid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02765 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cecropin-A(1-8)-melittin(1-18) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.4 microM)				[38]
Cecropin-D		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02771 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cecropin-D inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 24 microM)				[43]
Cecropin-P1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02774 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cecropin-P1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1.8 microM)				[44], [45]
Defensin MGD-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03110 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Defensin MGD-1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.8 microM)				[46]
Defensin sapecin-B		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04905 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Defensin sapecin-B inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[47], [48]
Defensin-like protein sesquin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03119 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Defensin-like protein sesquin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[49]
Dermaseptin-like PBN2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03162 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Dermaseptin-like PBN2 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.8 microM)				[50]
Dermatoxin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03164 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Dermatoxin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[51]
Drosophila cecropin-A1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03224 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Drosophila cecropin-A1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1-2.5 microM)				[52], [53]
Enkelytin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03249 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Enkelytin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.2-0.4 microM)				[54], [55]
Enterocin AS-48		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03251 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Enterocin AS-48 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[56]
Enterocin EJ97		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03254 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Enterocin EJ97 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 4 ug/ml)				[57]
Esculentin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03274 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Esculentin-1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.1 microM)				[31]
Esculentin-1B		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03277 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Esculentin-1B inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.1 microM)				[32]
Esculentin-2A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03299 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Esculentin-2A inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.2 microM)				[32]
Frog bombinin-like peptide BLP-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02474 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Frog bombinin-like peptide BLP-1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.3 microM)				[28]
Frog phylloxin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04575 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Frog phylloxin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3.12 microM)				[58]
Halocyntin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03522 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Halocyntin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[59]
Heligoland antimicrobial peptide A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04762 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Heligoland antimicrobial peptide A inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.1 microM)				[60]
Hevein-like antimicrobial peptide Ee-CBPb		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03243 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Hevein-like antimicrobial peptide Ee-CBPb inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[61], [62]
Hinnavin I		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03561 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Hinnavin I inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[63]
Human recombinant Ser-Thr-Ala-CGA1-78		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03605 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Human recombinant Ser-Thr-Ala-CGA1-78 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 30 microM)				[64]
Hymenoptaecin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03618 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Hymenoptaecin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.5-1 microM)				[65]
Immune protein P9		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02769 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Immune protein P9 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.44 microM)				[66]
Insect attacin-C		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02333 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Insect attacin-C inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC > 200 microM)				[67]
Insect cecropin-A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02768 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Insect cecropin-A inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1-2.5 ug/ml)				[68]
Insect cecropin-B		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02770 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Insect cecropin-B inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.64 microM)				[43], [69]
Insect cecropin-D		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02772 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Insect cecropin-D inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[66], [70]
Insect defensin A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03116 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Insect defensin A inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1.2-2.5 microM)				[71]
Insect defensin B		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03117 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Insect defensin B inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1.2-2.5 microM)				[71]
KR-12 peptide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03712 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	KR-12 peptide inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[72]
Lantibiotic lichenicidin VK21 A1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03804 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Lantibiotic lichenicidin VK21 A1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[73]
Lantibiotic lichenicidin VK21 A2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03805 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Lantibiotic lichenicidin VK21 A2 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[73]
Lunatusin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03973 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Lunatusin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[74]
Mammal mBMAP28		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04039 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mammal mBMAP28 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2 microM)				[35]
Melittin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04057 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Melittin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.6 microM)				[75]
Moricin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04128 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Moricin-1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.09 microM)				[76], [77]
Myeloid antimicrobial peptide BMAP-27		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04158 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Myeloid antimicrobial peptide BMAP-27 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2 microM)				[35]
Myeloid antimicrobial peptide BMAP-28		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04159 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Myeloid antimicrobial peptide BMAP-28 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2 microM)				[35]
Myticin-A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04166 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Myticin-A inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[78]
Myticin-B		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04167 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Myticin-B inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[78]
Myticusin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04168 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Myticusin-1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2.5-5.0 microM)				[79]
Mytilin-A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04169 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mytilin-A inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[80]
Napin-like polypeptide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04235 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Napin-like polypeptide inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[81]
Omwaprin-a		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04394 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Omwaprin-a inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[82], [83]
P. americana Pa-AMP-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04424 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P. americana Pa-AMP-1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[84], [85]
P18 analog N-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04206 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analog N-1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1.56 microM)				[41]
P18 analog N-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04214 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analog N-2 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.78 microM)				[41]
P18 analog N-3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04216 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analog N-3 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1.56 microM)				[41]
P18 analog N-3L		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04218 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analog N-3L inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.78 microM)				[41]
P18 analog N-4		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04219 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analog N-4 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1.56 microM)				[41]
P18 analog N-4L		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04220 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analog N-4L inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.78 microM)				[41]
P18 analog N-5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04221 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analog N-5 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1.56 microM)				[41]
P18 analog N-5L		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04222 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analog N-5L inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1.56 microM)				[41]
P18 analogue C-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02663 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analogue C-1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1.56 microM)				[41]
P18 analogue C-10		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02664 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analogue C-10 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3.125 microM)				[41]
P18 analogue C-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02672 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analogue C-2 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1.56 microM)				[41]
P18 analogue C-3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02673 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analogue C-3 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3.125 microM)				[41]
P18 analogue C-4		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02674 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analogue C-4 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3.125 microM)				[41]
P18 analogue C-5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02676 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analogue C-5 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1.56 microM)				[41]
P18 analogue C-6		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02677 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analogue C-6 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3.125 microM)				[41]
P18 analogue C-7		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02679 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analogue C-7 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3.125 microM)				[41]
P18 analogue C-8		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02680 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analogue C-8 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3.125 microM)				[41]
P18 analogue C-9		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02683 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analogue C-9 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3.125 microM)				[41]
P18 analogue L9		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01823 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analogue L9 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1.56 microM)				[41]
P18 analogue S9		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01825 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	P18 analogue S9 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3.125 microM)				[41]
Paneth cell-specific alpha-defensin 1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04463 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Paneth cell-specific alpha-defensin 1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[86]
Papillosin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04468 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Papillosin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[59]
Penaeidin-2d		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04506 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Penaeidin-2d inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2.5-5 microM)				[87], [88]
Penaeidin-3a		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04507 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Penaeidin-3a inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2.5-5 microM)				[89]
Penaeidin-3a T8A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01827 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Penaeidin-3a T8A inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3.12-6.25 microM)				[89]
Penaeidin-4a		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04510 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Penaeidin-4a inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC > 50 microM)				[87], [90]
Penaeidin-4d		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04511 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Penaeidin-4d inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC > 50 microM)				[87], [91]
Peptide leucine arginine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04545 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Peptide leucine arginine inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 20 microM)				[92]
Peptide PMAP-36(1-20)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04661 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Peptide PMAP-36(1-20) inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3 microM)				[93]
Peptide PMAP-36(1-34)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04662 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Peptide PMAP-36(1-34) inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1 microM)				[93]
Peptide PMAP-36(1-35)2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04663 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Peptide PMAP-36(1-35)2 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1 microM)				[93]
Perinerin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04546 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Perinerin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[94]
Pig DBI(32-86)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03081 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Pig DBI(32-86) inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.69 microM)				[4], [95]
Pilosulin P1(1-20)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04426 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Pilosulin P1(1-20) inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2 microM)				[96]
Plantazolicin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04624 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Plantazolicin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[97]
Plasticin ANC KF		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04625 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Plasticin ANC KF inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 12.5 microM)				[98]
Plasticin PD36 K		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04626 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Plasticin PD36 K inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 12.5 microM)				[98]
Plasticin PD36 KF		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04627 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Plasticin PD36 KF inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 50.25 microM)				[98]
Ponericin G1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04695 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin G1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[99]
Ponericin G4		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04697 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin G4 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[99]
Pore-forming peptide ameobapore A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04707 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Pore-forming peptide ameobapore A inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 13 microM)				[100]
Pyrrhocoricin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04770 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Pyrrhocoricin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC > 80 microM)				[101]
Ranacyclin-E		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04797 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ranacyclin-E inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3 microM)				[102]
Ranacyclin-T		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04798 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ranacyclin-T inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3 microM)				[102]
Recombinant Crassostrea Gigas Defensin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04840 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Recombinant Crassostrea Gigas Defensin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC > 20 microM)				[103]
Sapecin-C		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04906 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Sapecin-C inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[47]
Spheniscin-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04971 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Spheniscin-2 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.4-0.8 microM)				[104], [105]
Spider gomesin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03498 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Spider gomesin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.2-0.4 microM)				[21]
Spinigerin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04974 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Spinigerin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.8-1.5 microM)				[106], [107]
Stomoxyn		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04995 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Stomoxyn inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.78-1.56 microM)				[107], [108]
Subpeptin JM4-A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05004 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Subpeptin JM4-A inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[109]
Subpeptin JM4-B		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05005 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Subpeptin JM4-B inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[109]
Temporin-1Sa		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05063 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-1Sa inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2 microM)				[110]
Temporin-1Sb		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05064 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-1Sb inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 46 microM)				[110]
Temporin-1Sc		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05065 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-1Sc inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 4 ug/ml)				[110]
Temporin-A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05076 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-A inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 1.2 microM)				[111]
Temporin-B		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05085 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-B inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2.8 ug/ml)				[111]
Temporin-D		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05088 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-D inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[111], [112]
Temporin-SHa		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05105 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-SHa inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2 microM)				[110]
Termicin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05110 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Termicin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[106], [113]
Thanatin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05120 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Thanatin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2.5-5 microM)				[114], [115]
Thanatin truncated isoform Y12M(10-21)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05304 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Thanatin truncated isoform Y12M(10-21) inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 20-40 microM)				[114]
Thanatin truncated isoform G18C(1-18)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03431 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Thanatin truncated isoform G18C(1-18) inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 5-10 microM)				[114]
Thanatin truncated isoform G19Q(1-19)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03432 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Thanatin truncated isoform G19Q(1-19) inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 5-10 microM)				[114]
Thanatin truncated isoform G20R(1-20)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03435 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Thanatin truncated isoform G20R(1-20) inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2.5-5 microM)				[114]
Thanatin truncated isoform I14M(8-21)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03622 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Thanatin truncated isoform I14M(8-21) inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 10-20 microM)				[114]
Thanatin truncated isoform K18M(4-21)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03681 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Thanatin truncated isoform K18M(4-21) inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 2.5-5 microM)				[114]
Thanatin truncated isoform V16M(6-21)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05220 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Thanatin truncated isoform V16M(6-21) inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 5-10 microM)				[114]
Thuricin-17		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05138 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Thuricin-17 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[116]
TL(3)[Pro3,DLeu9]		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01824 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	TL(3)[Pro3,DLeu9] inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 3.125 microM)				[117]
Type 1 invertebrate defensin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03100 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Type 1 invertebrate defensin inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium				[118]
Vasostatin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05229 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Vasostatin-1 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.2 microM)				[64]
Venom antimicrobial peptide-6		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05230 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Venom antimicrobial peptide-6 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.25 microM)				[119]
Venom antimicrobial peptide-9		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05231 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Venom antimicrobial peptide-9 inhibits the drug-metabolizing activity of Cytochrome P450 21A2 (cyp21) from Bacillus megaterium (MIC = 0.25 microM)				[119]

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