General Information of DME (ID: DMEN074)
DME Name	Cytochrome P450 1A (CYP1A), .
Gene Name	CYP1A
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME

Full List of Drug(s) Metabolized by This DME
Drugs Approved by FDA			Click to Show/Hide the Full List of Drugs:          1 Drugs
Sunitinib malate	Drug Info	Approved	Renal cell carcinoma	ICD11: 2C90	[1]

Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF MR010978 Exjade Exjade Metabolite M1 Oxidation - Hydroxylation Exjade [2] MR010979 Exjade Exjade Metabolite M2 Oxidation - Hydroxylation Exjade [2] MR010980 Exjade Exjade Metabolite M4 Oxidation - Hydroxylation Exjade [2] MR002374 Telithromycin RU 76584 Oxidation - Oxidation Telithromycin [3], [4]

References
1	Acute pancreatitis in a patient treated with imatinib and gefitinib. J Oncol Pharm Pract. 2021 Jun;27(4):980-983. doi: 10.1177/1078155220949639.
2	Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats Drug Metab Dispos. 2008 Dec;36(12):2523-38. doi: 10.1124/dmd.108.022962.
3	Clinical pharmacokinetics of telithromycin, the first ketolide antibacterial. Clin Pharmacokinet. 2005;44(9):915-34.
4	Verapamil toxicity resulting from a probable interaction with telithromycin. Ann Pharmacother. 2005 Feb;39(2):357-60.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.