Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN096)
DME Name Cytochrome P450 3A1 (Cyp3a1), Rattus norvegicus
Gene Name Cyp3a1
UniProt ID
CP3A1_RAT
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Rattus norvegicus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
Order: .
Family: .
Genus: .
Species: Rattus norvegicus
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MDLLSALTLETWVLLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYMGLWKF
DVECHKKYGKIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDFGPVGIMGKAVSV
AKDEEWKRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAETGKPVTMKKVFGAYS
MDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYEMLNICM
FPKDSIEFFKKFVYRMKETRLDSVQKHRVDFLQLMMNAHNDSKDKESHTALSDMEITAQS
IIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMV
LNETLRLYPIGNRLERVCKKDVEINGVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERF
SKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSR
QGLLQPTKPIILKVVPRDEIITGS
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Metformin
 Drug Info Approved Type-2 diabetes ICD11: 5A11 [1]
Terazosin
 Drug Info Approved Prostatic hyperplasia ICD11: GA90 [2]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
AG-1549
 Drug Info Phase 1 Human immunodeficiency virus infection ICD11: 1C60 [3]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR003796 AG-1549 AG-1549 Metabolite C23 Oxidation - Oxidationn AG-1549 [3]
MR003811 AG-1549 AG-1549 Metabolite C19 Oxidation - Oxidationn AG-1549 [3]
MR003815 AG-1549 AG-1549 Metabolite C26 Oxidation - Oxidationn AG-1549 [3]
MR003821 AG-1549 AG-1549 Metabolite C20 Oxidation - Oxidationn AG-1549 [3]
MR003813 AG-1549 Metabolite C12 AG-1549 Metabolite C4 Unclear - Unclear AG-1549 [3]
MR003799 AG-1549 Metabolite C18 AG-1549 Metabolite C11 Oxidation - Oxidationn AG-1549 [3]
MR003799 AG-1549 Metabolite C18 AG-1549 Metabolite C11 Unclear - Unclear AG-1549 [3]
MR003814 AG-1549 Metabolite C19 AG-1549 Metabolite C9 Unclear - Unclear AG-1549 [3]
MR003801 AG-1549 Metabolite C22 AG-1549 Metabolite C11 Unclear - Unclear AG-1549 [3]
MR003797 AG-1549 Metabolite C23 AG-1549 Metabolite C25B Oxidation - Oxidationn AG-1549 [3]
MR003807 AG-1549 Metabolite C23 AG-1549 Metabolite C15 Oxidation - Oxidationn AG-1549 [3]
MR003800 AG-1549 Metabolite C25B AG-1549 Metabolite C22 Oxidation - Oxidationn AG-1549 [3]
MR003809 AG-1549 Metabolite C4 AG-1549 Metabolite C11 Unclear - Unclear AG-1549 [3]
MR003809 AG-1549 Metabolite C4 AG-1549 Metabolite C11 Unclear - Unclear AG-1549 [3]
MR003809 AG-1549 Metabolite C4 AG-1549 Metabolite C11 Unclear - Unclear AG-1549 [3]
MR003809 AG-1549 Metabolite C4 AG-1549 Metabolite C11 Unclear - Unclear AG-1549 [3]
MR003805 AG-1549 Metabolite C9 AG-1549 Metabolite C18 Oxidation - Oxidationn AG-1549 [3]
MR003806 AG-1549 Metabolite C9 AG-1549 Metabolite C3 Unclear - Unclear AG-1549 [3]
⏷ Show the Full List of 18 MR(s)
References
1 Pharmacokinetic interaction between DA-8159, a new erectogenic, and metformin in rats: competitive inhibition of metabolism via hepatic CYP3A1/2
2 Pharmacokinetic and pharmacodynamic consequences of inhibition of terazosin metabolism via CYP3A1 and/or 3A2 by DA-8159, an erectogenic, in rats
3 Evaluation of capravirine as a CYP3A probe substrate: in vitro and in vivo metabolism of capravirine in rats and dogs

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