Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN885)
DME Name Cytochrome P450 2B4 (CYP2B4), Oryctolagus cuniculus
Gene Name CYP2B4
UniProt ID
CP2B4_RABIT
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Oryctolagus cuniculus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
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Species: Oryctolagus cuniculus
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MEFSLLLLLAFLAGLLLLLFRGHPKAHGRLPPGPSPLPVLGNLLQMDRKGLLRSFLRLRE
KYGDVFTVYLGSRPVVVLCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGER
WRALRRFSLATMRDFGMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIIC
SIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFELFPGFLKHFPGTHRQIYRNLQE
INTFIGQSVEKHRATLDPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFFAGT
ETTSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLG
DLIPFGVPHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGAL
KRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNV
PPSYQIRFLAR
Structure
1PO5 ; 1SUO ; 2BDM ; 2Q6N ; 3G5N ; 3G93 ; 3KW4 ; 3ME6 ; 3MVR ; 3R1A ; 3R1B ; 3TK3 ; 3TMZ ; 3UAS ; 4H1N ; 4JLT ; 4MGJ ; 5EM4 ; 5IUT ; 5IUZ ; 6BWW
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Mitomycin
 Drug Info Approved Solid tumour/cancer ICD11: 2A00-2F9Z [1]
Levocarnitine
 Drug Info Approved Cognitive impairment ICD11: 6D71 [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR001474 Levocarnitine Inosine Oxidation - Deamination Levocarnitine [2]
References
1 Evaluation of bioreductive activation of anticancer drugs idarubicin and mitomycin C by NADH-cytochrome b5 reductase and cytochrome P450 2B4
2 Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase. J Struct Biol. 2004 Jun;146(3):416-24.

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