Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001474)
Formula
SVG example
Deamination
Reactant Levocarnitine Product Inosine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2B4 (CYP2B4) DME Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001473 Levocarnitine 6-N-trimethyllysine Unclear Levocarnitine [1]
MR001471 Levocarnitine Trimethylamine N-oxide Unclear Levocarnitine [2]
MR001472 Levocarnitine [3H]-gamma-butyrobetaine Unclear Levocarnitine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000077 Adenosine Inosine Oxidation - Deamination Adenosine [3], [4]
MR002342 Tasimelteon Inosine Oxidation - Hydroxylation Tasimelteon [5]
MR000081 Adenosine phosphate metabolite IMP Inosine Unclear Adenosine phosphate [6], [4]
References
1 Levocarnitine and muscle metabolism in patients with end-stage renal disease J Ren Nutr. 1998 Jul;8(3):118-21. doi: 10.1016/s1051-2276(98)90001-2.
2 DrugBank(Pharmacology-Metabolism)Levocarnitine
3 DrugBank(Pharmacology-Metabolism)Adenosine
4 Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data. Front Mol Neurosci. 2023 Feb 3;16:1089871. doi: 10.3389/fnmol.2023.1089871.
5 Clinical assessment of drug-drug interactions of tasimelteon, a novel dual melatonin receptor agonist. J Clin Pharmacol. 2015 Sep;55(9):1004-11.
6 Condition-dependent adenosine monophosphate decomposition pathways in striated adductor muscle from Japanese scallop (Patinopecten yessoensis) J Food Sci. 2020 May;85(5):1462-1469. doi: 10.1111/1750-3841.15142.

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