General Information of DME (ID: DMEN076)
DME Name	Aldehyde dehydrogenase (ALDH), .
Gene Name	ALDH
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME

Full List of Drug(s) Metabolized by This DME
Drugs Approved by FDA			Click to Show/Hide the Full List of Drugs:          8 Drugs
Fospropofol disodium	Drug Info	Approved	Monitored anaesthesia care	ICD11: N.A.	[1]
Almogran	Drug Info	Approved	Migraine	ICD11: 8A80	[2]
Dopamine hydrochloride	Drug Info	Approved	Parkinsonism	ICD11: 8A00	[3]
Cyclophosphamide	Drug Info	Approved	Multiple myeloma	ICD11: 2A83	[4]
Ibuprofen	Drug Info	Approved	Anaesthesia	ICD11: 8E22	[5]
Isovanillin	Drug Info	Approved	Solid tumour/cancer	ICD11: 2A00-2F9Z	[6]
Valaciclovir	Drug Info	Approved	Virus infection	ICD11: 1A24-1D9Z	[7]
Valacyclovir Hydrochloride	Drug Info	Approved	Herpes simplex virus infection	ICD11: 1F00	[7]
Drugs in Phase 3 Clinical Trial			Click to Show/Hide the Full List of Drugs:          1 Drugs
TRYPTAMINE	Drug Info	Phase 3	Discovery agent	ICD: N.A.	[8]
Drugs in Phase 2 Clinical Trial			Click to Show/Hide the Full List of Drugs:          1 Drugs
Ethanol	Drug Info	Phase 2	Diabetic nephropathy	ICD11: GB61	[9]
Discontinued/withdrawn Drugs			Click to Show/Hide the Full List of Drugs:          2 Drugs
Perillyl alcohol	Drug Info	Discontinued in Phase 2	Solid tumour/cancer	ICD11: 2A00-2F9Z	[10]
LF-08-0299	Drug Info	Discontinued	Diabetes mellitus	ICD11: 5A10	[11]
Preclinical/investigative Agents			Click to Show/Hide the Full List of Drugs:          1 Drugs
SC-47945	Drug Info	Investigative	Discovery agent	ICD: N.A.	[12]

Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF MR008996 Almogran 2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}acetic acid Oxidation - Oxidative deamination Almogran [13] MR008990 Almogran metabolite A2 Almogran metabolite P15 Unclear - Unclear Almogran [2] MR009947 4-Hydroxycyclophosphamide 4-Ketocyclophosphamide Unclear - Unclear Cyclophosphamide [4] MR009945 Aldophosphamide Carboxyphosphamide Unclear - Unclear Cyclophosphamide [4] MR006627 DHPA DOPAC Unclear - Unclear Dopamine hydrochloride [3] MR006631 MHPA HVA Unclear - Unclear Dopamine hydrochloride [3] MR007846 Formaldehyde Formic acid Unclear - Unclear Fospropofol disodium [1] MR002003 2-Phenoxybenzaldehyde 2-Phenoxybenzoic acid Oxidation - Oxidation Permethrin [14] MR010679 Safinamide Metabolite M2 NW-1689 Unclear - Unclear Safinamide [15] MR010679 Safinamide Metabolite M2 NW-1689 Unclear - Unclear Safinamide [15] MR010679 Safinamide Metabolite M2 NW-1689 Unclear - Unclear Safinamide [15] MR014062 Safinamide Metabolite M2 NW-1689 Unclear - Unclear Safinamide [15] MR006362 SC-47945 DOPAC Unclear - Unclear SC-47945 [12] MR013629 T-2513 T-1335 Unclear - Unclear T-0128 [16] MR006778 4-Hydroxy tolbutamide 4-Carboxytolbutamide Unclear - Unclear Tolbutamide [17] ⏷ Show the Full List of 15 MR(s)

References
1	Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects
2	Almotriptan, a new anti-migraine agent: a review. CNS Drug Rev. 2002 Fall;8(3):217-34.
3	Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain
4	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
5	Genetic Characterization of the Ibuprofen-Degradative Pathway of Rhizorhabdus wittichii MPO218
6	Metabolism of isovanillin by aldehyde oxidase, xanthine oxidase, aldehyde dehydrogenase and liver slices
7	Absolute bioavailability and metabolic disposition of valaciclovir, the L-valyl ester of acyclovir, following oral administration to humans
8	Tryptamine: a metabolite of tryptophan implicated in various neuropsychiatric disorders
9	Ethanol Metabolism in the Liver, the Induction of Oxidant Stress, and the Antioxidant Defense System
10	Cytotoxicity and biotransformation of the anticancer drug perillyl alcohol in PC12 cells and in the rat
11	Metabolism of tresperimus by rat aorta semicarbazide-sensitive amine oxidase (SSAO). Fundam Clin Pharmacol. 2002 Dec;16(6):461-70.
12	Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev. 2007 Jun;59(2):125-50.
13	DrugBank(Pharmacology-Metabolism):Almogran
14	Human metabolic interactions of environmental chemicals. J Biochem Mol Toxicol. 2007;21(4):182-6.
15	Effects of ketoconazole treatment on the pharmacokinetics of safinamide and its plasma metabolites in healthy adult subjects
16	Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors
17	Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes

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