Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5454)
Drug Name
Fospropofol disodium
Synonyms Lusedra (TN)
Indication Monitored anaesthesia care [ICD11: N.A.] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 332.24 Topological Polar Surface Area 81.6
Heavy Atom Count 21 Rotatable Bond Count 5
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 5
Cross-matching ID
PubChem CID
3038497
CAS Number
258516-87-9
TTD Drug ID
D02EZM
Formula
C13H19Na2O5P
Canonical SMILES
CC(C)C1=C(C(=CC=C1)C(C)C)OCOP(=O)([O-])[O-].[Na+].[Na+]
InChI
InChI=1S/C13H21O5P.2Na/c1-9(2)11-6-5-7-12(10(3)4)13(11)17-8-18-19(14,15)16;;/h5-7,9-10H,8H2,1-4H3,(H2,14,15,16);;/q;2*+1/p-2
InChIKey
LWYLQNWMSGFCOZ-UHFFFAOYSA-L
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Formaldehyde DM001748
712
Unclear - Unclear 1 [2]
Phosphate DM003103
1061
Unclear - Unclear 1 [2]
Propofol DM003080
4943
Unclear - Unclear 1 [2]
2-(omega-Propanol)-6-isopropyl-phenol DM016499
102242077
Unclear - Unclear 2 [2]
4-hydroxypropofol DM002068
3014064
Unclear - Unclear 2 [2]
Formic acid DM000198
284
Unclear - Unclear 2 [2]
Propofol-O-glucuronide DM016963 N. A. Conjugation - O-glucuronidation 2 [2]
Propofol-O-sulfate DM015828
13356592
Unclear - Unclear 2 [2]
1-Hydroxypropofol-O-glucuronide DM016470
101649831
Unclear - Unclear 3 [2]
2,6-Diisopropyl-1,4-quinone DM015333
642540
Conjugation - O-glucuronidation 3 [2]
2-(omega-Propanol)-6-isopropyl-1,4-quinol DM016500
102242078
Unclear - Unclear 3 [2]
2-(omega-Propanol)-6-isopropyl-phenol-O-glucuronide DM016962 N. A. Unclear - Unclear 3 [2]
4-Hydroxypropofol-O-glucuronide DM016471
101649832
Unclear - Unclear 3 [2]
4-Hydroxypropofol-O-sulphate DM003010
10446031
Unclear - Unclear 3 [2]
CO2 DM000908
280
Unclear - Unclear 3 [2]
H2O DM000368
962
Unclear - Unclear 3 [2]
2-(omega-Propanol)-4-hydroxypropofol-O-sulfate DM016960 N. A. Unclear - Unclear 4 [2]
2-(omega-Propanol)-6-isopropyl-1,4-quinol-O-glucuronide DM016961 N. A. Unclear - Unclear 4 [2]
⏷ Show the Full List of 18  DM(s)
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR007834 Fospropofol disodium Propofol Unclear - Unclear ALPL [2]
MR007845 Fospropofol disodium Formaldehyde Unclear - Unclear Unclear [2]
MR007851 Fospropofol disodium Phosphate Unclear - Unclear Unclear [2]
MR007846 Formaldehyde Formic acid Unclear - Unclear ALDH [2]
MR007835 Propofol 4-Hydroxypropofol Unclear - Unclear CYP2B6 ... [2]
MR007843 Propofol 2-(omega-Propanol)-6-isopropyl-phenol Unclear - Unclear Unclear [2]
MR007849 Propofol Propofol-O-sulfate Unclear - Unclear Unclear [2]
MR007850 Propofol Propofol-O-glucuronide Conjugation - O-glucuronidation UGT1A9 ... [2]
MR007844 2-(omega-Propanol)-6-isopropyl-phenol 2-(omega-Propanol)-6-isopropyl-phenol-O-glucuronide Unclear - Unclear Unclear [2]
MR007836 4-Hydroxypropofol 4-Hydroxypropofol-O-sulphate Unclear - Unclear SULT [2]
MR007838 4-Hydroxypropofol 2-(omega-Propanol)-6-isopropyl-1,4-quinol Unclear - Unclear Unclear [2]
MR007840 4-Hydroxypropofol 2,6-Diisopropyl-1,4-quinone Conjugation - O-glucuronidation NQO1 [2]
MR007841 4-Hydroxypropofol 1-Hydroxypropofol-O-glucuronide Unclear - Unclear UGT [2]
MR007842 4-Hydroxypropofol 4-Hydroxypropofol-O-glucuronide Unclear - Unclear UGT [2]
MR007847 Formic acid CO2 Unclear - Unclear Unclear [2]
MR007848 Formic acid H2O Unclear - Unclear Unclear [2]
MR007839 2-(omega-Propanol)-6-isopropyl-1,4-quinol 2-(omega-Propanol)-6-isopropyl-1,4-quinol-O-glucuronide Unclear - Unclear Unclear [2]
MR007837 4-Hydroxypropofol-O-sulphate 2-(omega-Propanol)-4-hydroxypropofol-O-sulfate Unclear - Unclear Unclear [2]
⏷ Show the Full List of 18 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Alcohol dehydrogenase class-III (ADH5) DME0132 Homo sapiens
ADHX_HUMAN
1.1.1.1
[2]
Aldehyde dehydrogenase (ALDH) DMEN076 . Not Available Not Available [2]
Alkaline phosphatase (ALP) DME1774 Capnocytophaga gingivalis
A0A250FL93_9FLAO
3.1.3.1
[3]
Cytochrome P450 1A2 (CYP1A2) DME0003 Homo sapiens
CP1A2_HUMAN
1.14.14.1
[2]
Cytochrome P450 2B6 (CYP2B6) DME0020 Homo sapiens
CP2B6_HUMAN
1.14.14.1
[2]
Cytochrome P450 2C18 (CYP2C18) DME0017 Homo sapiens
CP2CI_HUMAN
1.14.14.1
[2]
Cytochrome P450 2C8 (CYP2C8) DME0018 Homo sapiens
CP2C8_HUMAN
1.14.14.1
[2]
Cytochrome P450 2C9 (CYP2C9) DME0019 Homo sapiens
CP2C9_HUMAN
1.14.14.1
[2]
Cytochrome P450 2E1 (CYP2E1) DME0013 Homo sapiens
CP2E1_HUMAN
1.14.14.1
[2]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Homo sapiens
CP2CJ_HUMAN
1.14.14.1
[2]
Quinone reductase 1 (NQO1) DME0097 Homo sapiens
NQO1_HUMAN
1.6.5.2
[2]
Sulfotransferase (SULT) DMEN061 . Not Available Not Available [2]
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME0075 Homo sapiens
UD110_HUMAN
2.4.1.17
[2]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME0072 Homo sapiens
UD16_HUMAN
2.4.1.17
[2]
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME0065 Homo sapiens
UD17_HUMAN
2.4.1.17
[2]
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME0064 Homo sapiens
UD18_HUMAN
2.4.1.17
[2]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042 Homo sapiens
UD19_HUMAN
2.4.1.17
[2]
⏷ Show the Full List of 17  DME(s)
References
1 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
2 Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects
3 DrugBank(Pharmacology-Metabolism):Fospropofol disodium

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