Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM002217)
DM Name	Nitrofurantoin metabolite M10

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2A6 (CYP2A6)	DME0005	Nitrofurantoin	Oxidation - Oxidation	Nitrofurantoin	[1]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Nitrofurantoin	Oxidation - Oxidation	Nitrofurantoin	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Cytochrome P450 2A6 (CYP2A6)	DME0005	Nitrofurantoin metabolite 8(M1/M2)	Oxidation - Oxidation	Nitrofurantoin	[1]
Cytochrome P450 2A6 (CYP2A6)	DME0005	Nitrofurantoin metabolite 9(M1/M2)	Oxidation - Oxidation	Nitrofurantoin	[1]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Nitrofurantoin metabolite 8(M1/M2)	Oxidation - Oxidation	Nitrofurantoin	[1]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Nitrofurantoin metabolite 9(M1/M2)	Oxidation - Oxidation	Nitrofurantoin	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Nitrofurantoin		DR1169	Approved		Infectious cystitis

References
1	Oxidative bioactivation of nitrofurantoin in rat liver microsomes Xenobiotica. 2017 Feb;47(2):103-111. doi: 10.3109/00498254.2016.1164913.

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