| General Information of Drug Metabolite (DM) (ID: DM002505) |
| DM Name |
BPI-2009 metabolite M4
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 1A2 (CYP1A2)
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DME0003
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| Oxidation - Oxidation |
BPI-2009
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[1] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Oxidation |
BPI-2009
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[1] |
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Cytochrome P450 3A5 (CYP3A5)
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DME0012
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| Oxidation - Oxidation |
BPI-2009
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| BPI-2009 |
DR0851
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Phase 3 |
Lung cancer |
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| References |
| 1 |
Metabolic pathway of icotinib in vitro: the differential roles of CYP3A4, CYP3A5, and CYP1A2 on potential pharmacokinetic drug-drug interaction. J Pharm Sci. 2018 Apr;107(4):979-983.
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