| General Information of Drug Metabolite (DM) (ID: DM002716) |
| DM Name |
Nimesulide metabolite M2
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 1A2 (CYP1A2)
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DME0003
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| Unclear - Unclear |
Nimesulide
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[1] |
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Mephenytoin 4-hydroxylase (CYP2C19)
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DME0021
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| Unclear - Unclear |
Nimesulide
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[1] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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Prostaglandin G/H synthase 2 (COX-2)
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DME0114
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| Unclear - Unclear |
Nimesulide
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Nimesulide |
DR1160
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Phase 4 |
Anaesthesia |
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| References |
| 1 |
Neutrophil- and myeloperoxidase-mediated metabolism of reduced nimesulide: evidence for bioactivation Chem Res Toxicol. 2010 Nov 15;23(11):1691-700. doi: 10.1021/tx1001496.
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