General Information of Drug Metabolite (DM) (ID: DM002833)
DM Name
Labetalol Phenolic glucuronide metabolite (III)
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004 Conjugation - O-Glucuronidation Labetalol [1] , [2]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042 Conjugation - O-Glucuronidation Labetalol [1] , [2]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040 Conjugation - O-Glucuronidation Labetalol [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Labetalol DR0909 Approved Essential hypertension
References
1 Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination. Xenobiotica. 2008 Jan;38(1):62-75.
2 Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes Front Pharmacol. 2021 Apr 15;12:655320. doi: 10.3389/fphar.2021.655320.

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