Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM004089)
DM Name	9,10-Phenanthrene hydroquinone

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Quinone reductase 1 (NQO1)	DME0097	Phenanthrenequinone	Reduction - Reduction	Phenanthrenequinone	[1] , [2]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Catechol O-methyltransferase (COMT)	DME0043	O-mono-methyl-O-mono-sulfonated catechol	Unclear - Unclear	Phenanthrenequinone	[1]
Catechol O-methyltransferase (COMT)	DME0043	O-mono-methyl catechol	Unclear - Unclear	Phenanthrenequinone	[1]
Sulfotransferase 1A1 (SULT1A1)	DME0008	O-mono-methyl-O-mono-sulfonated catechol	Unclear - Unclear	Phenanthrenequinone	[1]
Sulfotransferase 1A1 (SULT1A1)	DME0008	O-mono-sulfonated catechol	Unclear - Unclear	Phenanthrenequinone	[1]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DME0004	O-mono-glucuronosyl catechol	Unclear - Unclear	Phenanthrenequinone	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Phenanthrenequinone		DR0026	Investigative		Discovery agent

References
1	Metabolism of a representative oxygenated polycyclic aromatic hydrocarbon (PAH) phenanthrene-9,10-quinone in human hepatoma (HepG2) cells
2	Cytotoxicity of Air Pollutant 9,10-Phenanthrenequinone: Role of Reactive Oxygen Species and Redox Signaling

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