Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM004278)
DM Name	GS-563117

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Aldehyde oxidase (AOX1)	DME0052	Idelalisib	Unclear - Unclear	Idelalisib	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Idelalisib	Unclear - Unclear	Idelalisib	[1] , [2]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	Idelalisib Metabolite M20	Unclear - Unclear	Idelalisib	[2]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Idelalisib Metabolite M19	Unclear - Unclear	Idelalisib	[2]
Cytochrome P450 2D6 (CYP2D6)	DME0009	Idelalisib Metabolite M19	Unclear - Unclear	Idelalisib	[2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Idelalisib Metabolite M20	Unclear - Unclear	Idelalisib	[2]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Idelalisib Metabolite M19	Unclear - Unclear	Idelalisib	[2]

Full List of Drug(s) That Produce This DM By Metabolism
Idelalisib		DR0854	Approved		Chronic lymphocytic leukaemia

References
1	Clinical drug interaction profile of idelalisib in healthy subjects
2	Identification of Novel Pathways in Idelalisib Metabolism and Bioactivation

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.