Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM004313)
DM Name	M7 N-oxidation imatinib

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A1 (CYP1A1)	DME0006	Imatinib mesylate	Oxidation - N-oxidation	Imatinib mesylate	[1]
Cytochrome P450 1A2 (CYP1A2)	DME0003	Imatinib mesylate	Oxidation - N-oxidation	Imatinib mesylate	[1]
Cytochrome P450 1B1 (CYP1B1)	DME0023	Imatinib mesylate	Oxidation - N-oxidation	Imatinib mesylate	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Imatinib mesylate	Oxidation - N-oxidation	Imatinib mesylate	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Imatinib mesylate		DR0858	Approved		Chronic myelogenous leukaemia

References
1	In vitro biotransformation of imatinib by the tumor expressed CYP1A1 and CYP1B1

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