General Information of Drug Metabolite (DM) (ID: DM004732)
DM Name
1-chloro-2,2,2-trifluoroethanide
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 2A6 (CYP2A6) DME0005 Reduction - Dehalogenation Halothane [1] , [2]
Cytochrome P450 2B6 (CYP2B6) DME0020 Reduction - Dehalogenation Halothane [1] , [2]
Cytochrome P450 2C9 (CYP2C9) DME0019 Reduction - Dehalogenation Halothane [1] , [2]
Cytochrome P450 2D6 (CYP2D6) DME0009 Reduction - Dehalogenation Halothane [1] , [2]
Cytochrome P450 3A4 (CYP3A4) DME0001 Reduction - Dehalogenation Halothane [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Halothane DR0803 Approved Anaesthesia
References
1 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
2 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.

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