| General Information of Drug Metabolite (DM) (ID: DM004927) |
| DM Name |
N-desmethyl cyamemazine
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 1A2 (CYP1A2)
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DME0003
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| Oxidation - N-demethylation |
Cyamemazine
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[1] , [2] |
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Cytochrome P450 2C8 (CYP2C8)
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DME0018
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| Oxidation - N-demethylation |
Cyamemazine
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[1] , [2] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - N-demethylation |
Cyamemazine
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[1] , [2] |
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Mephenytoin 4-hydroxylase (CYP2C19)
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DME0021
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| Oxidation - N-demethylation |
Cyamemazine
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Cyamemazine |
DR0388
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Investigative |
Discovery agent |
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| References |
| 1 |
Active cyamemazine metabolites in patients treated with cyamemazine (Tercian?): influence on cerebral dopamine D2 and serotonin 5-HT (2A) receptor occupancy as measured by positron emission tomography (PET)
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| 2 |
Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine. Eur J Pharm Sci. 2007 Dec;32(4-5):357-66.
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