| General Information of Drug Metabolite (DM) (ID: DM005094) |
| DM Name |
Lonafarnib metabolite M1
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Oxidationn |
Lonafarnib
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[1] , [2] |
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Cytochrome P450 3A5 (CYP3A5)
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DME0012
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| Oxidation - Oxidationn |
Lonafarnib
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[1] , [2] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Other reaction - Dehydration |
Lonafarnib
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[1] , [2] |
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Cytochrome P450 3A5 (CYP3A5)
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DME0012
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| Other reaction - Dehydration |
Lonafarnib
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Lonafarnib |
DR5975
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Approved |
Progeria |
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| References |
| 1 |
Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar). Drug Metab Dispos. 2006 Apr;34(4):628-35.
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| 2 |
Identification of unstable metabolites of Lonafarnib using liquid chromatography-quadrupole time-of-flight mass spectrometry, stable isotope incorporation and ion source temperature alteration
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