General Information of Drug Metabolite (DM) (ID: DM005095)
DM Name
Lonafarnib metabolite M2
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Other reaction - Dehydration Lonafarnib [1] , [2]
Cytochrome P450 3A5 (CYP3A5) DME0012 Other reaction - Dehydration Lonafarnib [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Lonafarnib DR5975 Approved Progeria
References
1 Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar). Drug Metab Dispos. 2006 Apr;34(4):628-35.
2 Identification of unstable metabolites of Lonafarnib using liquid chromatography-quadrupole time-of-flight mass spectrometry, stable isotope incorporation and ion source temperature alteration

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