| General Information of Drug Metabolite (DM) (ID: DM006459) |
| DM Name |
Macitentan metabolite M7
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2C8 (CYP2C8)
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DME0018
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| Oxidation - Hydrolyzationn |
Macitentan
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[1] |
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Cytochrome P450 2C9 (CYP2C9)
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DME0019
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| Oxidation - Hydrolyzationn |
Macitentan
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[1] |
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Mephenytoin 4-hydroxylase (CYP2C19)
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DME0021
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| Oxidation - Hydrolyzationn |
Macitentan
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Macitentan |
DR0998
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Approved |
Pulmonary hypertension |
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| References |
| 1 |
Clinical pharmacokinetics and pharmacodynamics of the endothelin receptor antagonist macitentan
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