Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM017875)
DM Name	Darexaban glucuronide
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
UDP-glucuronosyltransferase 1A10 (UGT1A10)	DME0075	Darexaban maleate	Unclear - Unclear	Darexaban maleate	[1] , [2]
UDP-glucuronosyltransferase 1A7 (UGT1A7)	DME0065	Darexaban maleate	Unclear - Unclear	Darexaban maleate	[1] , [2]
UDP-glucuronosyltransferase 1A8 (UGT1A8)	DME0064	Darexaban maleate	Unclear - Unclear	Darexaban maleate	[1] , [2]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DME0042	Darexaban maleate	Unclear - Unclear	Darexaban maleate	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Darexaban maleate		DR3055	Discontinued in Phase 3		Acute coronary syndrome

References
1	Absorption, metabolism and excretion of darexaban (YM150), a new direct factor Xa inhibitor in humans
2	Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine

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