General Information of Drug Metabolite (DM) (ID: DM019634)
DM Name
LIK-066 M17,27
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042 Multi-steps Reaction - Oxidation; direct glucuronidation LIK-066 [1]
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME0047 Multi-steps Reaction - Oxidation; direct glucuronidation LIK-066 [1]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040 Multi-steps Reaction - Oxidation; direct glucuronidation LIK-066 [1]
Full List of Drug(s) That Produce This DM By Metabolism
LIK-066 DR3265 Phase 2 Heart failure
References
1 Pharmacokinetics, metabolism, and excretion of licogliflozin, a dual inhibitor of SGLT1/2, in rats, dogs, and humans

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