General Information of Drug Metabolite (DM) (ID: DM019755)
DM Name
JI-101 M1
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 1A1 (CYP1A1) DME0006 Oxidation - Dihydroxylation JI-101 [1]
Cytochrome P450 2C8 (CYP2C8) DME0018 Oxidation - Dihydroxylation JI-101 [1]
Cytochrome P450 2D6 (CYP2D6) DME0009 Oxidation - Dihydroxylation JI-101 [1]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Dihydroxylation JI-101 [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Oxidation - Dihydroxylation JI-101 [1]
Full List of Drug(s) That Produce This DM By Metabolism
JI-101 DR3254 Phase 2 Solid tumour/cancer
References
1 Pharmacokinetics, tissue distribution and identification of putative metabolites of JI-101 - a novel triple kinase inhibitor in rats

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